caa a22 4500 606202714 CHVBK 20210128100954.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00429-014-0772-2 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0772-2 Abnormalities in structural covariance of cortical gyrification in schizophrenia [Elektronische Daten] [Lena Palaniyappan, Bert Park, Vijender Balain, Raj Dangi, Peter Liddle] The highly convoluted shape of the adult human brain results from several well-coordinated maturational events that start from embryonic development and extend through the adult life span. Disturbances in these maturational events can result in various neurological and psychiatric disorders, resulting in abnormal patterns of morphological relationship among cortical structures (structural covariance). Structural covariance can be studied using graph theory-based approaches that evaluate topological properties of brain networks. Covariance-based graph metrics allow cross-sectional study of coordinated maturational relationship among brain regions. Disrupted gyrification of focal brain regions is a consistent feature of schizophrenia. However, it is unclear if these localized disturbances result from a failure of coordinated development of brain regions in schizophrenia. We studied the structural covariance of gyrification in a sample of 41 patients with schizophrenia and 40 healthy controls by constructing gyrification-based networks using a 3-dimensional index. We found that several key regions including anterior insula and dorsolateral prefrontal cortex show increased segregation in schizophrenia, alongside reduced segregation in somato-sensory and occipital regions. Patients also showed a lack of prominence of the distributed covariance (hubness) of cingulate cortex. The abnormal segregated folding pattern in the right peri-sylvian regions (insula and fronto-temporal cortex) was associated with greater severity of illness. The study of structural covariance in cortical folding supports the presence of subtle deviation in the coordinated development of cortical convolutions in schizophrenia. The heterogeneity in the severity of schizophrenia could be explained in part by aberrant trajectories of neurodevelopment. The Author(s), 2014 Gyrification nationallicence Segregation nationallicence Integration nationallicence Connectome nationallicence Centrality nationallicence Topology and graph theory nationallicence Palaniyappan Lena Division of Psychiatry and Applied Psychology, University of Nottingham, Room-09, C Floor, Institute of Mental Health Building, Triumph Road, NG7 2TU, Nottingham, England, UK aut Park Bert Early Intervention in Psychosis, Nottinghamshire Healthcare NHS Trust, Nottingham, UK aut Balain Vijender Penticton Regional Hospital, 550 Carmi Avenue, V2A 3GS, Penticton, UK aut Dangi Raj Lancashirecare NHS Foundation Trust, Preston Road, PR7 1PP, Chorley, UK aut Liddle Peter Division of Psychiatry and Applied Psychology, University of Nottingham, Room-09, C Floor, Institute of Mental Health Building, Triumph Road, NG7 2TU, Nottingham, England, UK aut Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 2059-2071 1863-2653 220:4<2059 2015 220 429 https://doi.org/10.1007/s00429-014-0772-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0772-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Palaniyappan Lena Division of Psychiatry and Applied Psychology, University of Nottingham, Room-09, C Floor, Institute of Mental Health Building, Triumph Road, NG7 2TU, Nottingham, England, UK aut NATIONALLICENCE 700 1- Park Bert Early Intervention in Psychosis, Nottinghamshire Healthcare NHS Trust, Nottingham, UK aut NATIONALLICENCE 700 1- Balain Vijender Penticton Regional Hospital, 550 Carmi Avenue, V2A 3GS, Penticton, UK aut NATIONALLICENCE 700 1- Dangi Raj Lancashirecare NHS Foundation Trust, Preston Road, PR7 1PP, Chorley, UK aut NATIONALLICENCE 700 1- Liddle Peter Division of Psychiatry and Applied Psychology, University of Nottingham, Room-09, C Floor, Institute of Mental Health Building, Triumph Road, NG7 2TU, Nottingham, England, UK aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 2059-2071 1863-2653 220:4<2059 2015 220 429