caa a22 4500 606202722 CHVBK 20210128100954.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00429-014-0769-x doi (NATIONALLICENCE)springer-10.1007/s00429-014-0769-x Childhood adversity, depression, age and gender effects on white matter microstructure: a DTI study [Elektronische Daten] [Izuchukwu Ugwu, Francesco Amico, Angela Carballedo, Andrew Fagan, Thomas Frodl] Previous diffusion tensor imaging (DTI) studies have shown that various factors can affect white matter (WM) tract diffusivity. The aim of the present study was to investigate the effects of childhood adversity (CA), age and gender on WM diffusivity in tracts that are thought to be involved in emotional regulation in individuals with major depressive disorder (MDD) and healthy controls (HC). DTI was obtained from 46 subjects with MDD and 46 HC subjects. Data were pre-processed and deterministic tractography was applied in the cingulum, uncinate fasciculus (UF), fornix, superior longitudinal fasciculus (SLF) and fronto-occipital fasciculus (FOF). In subjects with a history of CA, fractional anisotropy (FA) was greater in the rostral cingulum (RC) and dorsal cingulum, whereas radial diffusivity (RD) was smaller in the RC when compared with subjects with no history of CA. In the UF, FOF and parahippocampal cingulum, FA was greater in the left hemisphere in the subjects with CA when compared with those without CA. Age affected FA, longitudinal diffusivity and RD in the UF, fornix, FOF and SLF, reflecting axonal and myelin degeneration with increasing age. Depression or gender did not have any effects on the diffusivity measures. Due to the cross-sectional nature of the study, a recall bias for CA and possible effects of medical treatment on diffusivity measures could have played a role. CA and age could increase the likelihood to develop WM microstructural anomalies in the brain affective network. Moreover, subjects with CA could be more vulnerable to FA changes. Springer-Verlag Berlin Heidelberg, 2014 Childhood adversity nationallicence Age nationallicence White matter nationallicence Major depressive disorder nationallicence DTI nationallicence Ugwu Izuchukwu Adelaide and Meath Hospital Incorporating the National Children's Hospital, Tallaght, Dublin 24, Dublin, Ireland aut Amico Francesco Department of Psychiatry, School of Medicine, Trinity College Dublin, College Green, Dublin 2, Ireland aut Carballedo Angela Adelaide and Meath Hospital Incorporating the National Children's Hospital, Tallaght, Dublin 24, Dublin, Ireland aut Fagan Andrew St. James's Hospital, Centre of Advanced Medical Imaging (CAMI), James's Street, Dublin 8, Dublin, Ireland aut Frodl Thomas Adelaide and Meath Hospital Incorporating the National Children's Hospital, Tallaght, Dublin 24, Dublin, Ireland aut Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 1997-2009 1863-2653 220:4<1997 2015 220 429 https://doi.org/10.1007/s00429-014-0769-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0769-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ugwu Izuchukwu Adelaide and Meath Hospital Incorporating the National Children's Hospital, Tallaght, Dublin 24, Dublin, Ireland aut NATIONALLICENCE 700 1- Amico Francesco Department of Psychiatry, School of Medicine, Trinity College Dublin, College Green, Dublin 2, Ireland aut NATIONALLICENCE 700 1- Carballedo Angela Adelaide and Meath Hospital Incorporating the National Children's Hospital, Tallaght, Dublin 24, Dublin, Ireland aut NATIONALLICENCE 700 1- Fagan Andrew St. James's Hospital, Centre of Advanced Medical Imaging (CAMI), James's Street, Dublin 8, Dublin, Ireland aut NATIONALLICENCE 700 1- Frodl Thomas Adelaide and Meath Hospital Incorporating the National Children's Hospital, Tallaght, Dublin 24, Dublin, Ireland aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 1997-2009 1863-2653 220:4<1997 2015 220 429