caa a22 4500 606202781 CHVBK 20210128100954.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00429-014-0785-x doi (NATIONALLICENCE)springer-10.1007/s00429-014-0785-x Imaging changes associated with cognitive abnormalities in Parkinson's disease [Elektronische Daten] [Yuko Koshimori, Barbara Segura, Leigh Christopher, Nancy Lobaugh, Sarah Duff-Canning, Romina Mizrahi, Clement Hamani, Anthony Lang, Kelly Aminian, Sylvain Houle, Antonio Strafella] The current study investigates both gray and white matter changes in non-demented Parkinson's disease (PD) patients with varying degrees of mild cognitive deficits and elucidates the relationships between the structural changes and clinical sequelae of PD. Twenty-six PD patients and 15 healthy controls (HCs) were enrolled in the study. Participants underwent T1-weighted and diffusion tensor imaging (DTI) scans. Their cognition was assessed using a neuropsychological battery. Compared with HCs, PD patients showed significant cortical thinning in sensorimotor (left pre- and postcentral gyri) and cognitive (left dorsolateral superior frontal gyrus [DLSFG]) regions. The DLSFG cortical thinning correlated with executive and global cognitive impairment in PD patients. PD patients showed white matter abnormalities as well, primarily in bilateral frontal and temporal regions, which also correlated with executive and global cognitive impairment. These results seem to suggest that both gray and white matter changes in the frontal regions may constitute an early pathological substrate of cognitive impairment of PD providing a sensitive biomarker for brain changes in PD. Springer-Verlag Berlin Heidelberg, 2014 Parkinson's disease nationallicence Cognition nationallicence Executive dysfunction nationallicence Cortical thickness nationallicence White matter nationallicence Diffusion tensor imaging nationallicence Koshimori Yuko Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, 399 Bathurst St, M5T 2S8, Toronto, ON, Canada aut Segura Barbara Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), University of Toronto, 250 College St, M5T 1R8, Toronto, ON, Canada aut Christopher Leigh Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, 399 Bathurst St, M5T 2S8, Toronto, ON, Canada aut Lobaugh Nancy Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), University of Toronto, 250 College St, M5T 1R8, Toronto, ON, Canada aut Duff-Canning Sarah Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, 399 Bathurst St, M5T 2S8, Toronto, ON, Canada aut Mizrahi Romina Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), University of Toronto, 250 College St, M5T 1R8, Toronto, ON, Canada aut Hamani Clement Division of Neurosurgery, Toronto Western Hospital, UHN, University of Toronto, 399 Bathurst St, M5T 2S8, Toronto, ON, Canada aut Lang Anthony Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, 399 Bathurst St, M5T 2S8, Toronto, ON, Canada aut Aminian Kelly Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, 399 Bathurst St, M5T 2S8, Toronto, ON, Canada aut Houle Sylvain Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), University of Toronto, 250 College St, M5T 1R8, Toronto, ON, Canada aut Strafella Antonio Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, 399 Bathurst St, M5T 2S8, Toronto, ON, Canada aut Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 2249-2261 1863-2653 220:4<2249 2015 220 429 https://doi.org/10.1007/s00429-014-0785-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0785-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koshimori Yuko Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, 399 Bathurst St, M5T 2S8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Segura Barbara Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), University of Toronto, 250 College St, M5T 1R8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Christopher Leigh Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, 399 Bathurst St, M5T 2S8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Lobaugh Nancy Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), University of Toronto, 250 College St, M5T 1R8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Duff-Canning Sarah Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, 399 Bathurst St, M5T 2S8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Mizrahi Romina Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), University of Toronto, 250 College St, M5T 1R8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Hamani Clement Division of Neurosurgery, Toronto Western Hospital, UHN, University of Toronto, 399 Bathurst St, M5T 2S8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Lang Anthony Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, 399 Bathurst St, M5T 2S8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Aminian Kelly Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, 399 Bathurst St, M5T 2S8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Houle Sylvain Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), University of Toronto, 250 College St, M5T 1R8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Strafella Antonio Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, 399 Bathurst St, M5T 2S8, Toronto, ON, Canada aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/4(2015-07-01), 2249-2261 1863-2653 220:4<2249 2015 220 429