caa a22 4500 606202811 CHVBK 20210128100954.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00429-014-0840-7 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0840-7 Spinal cord projections to the cerebellum in the mouse [Elektronische Daten] [Gulgun Sengul, YuHong Fu, You Yu, George Paxinos] The projections from the spinal cord to the cerebellar cortex were studied using retrograde neuronal tracers. Thus far, no study has shown the detailed topographic mapping of the projections from the spinal neuron clusters to the cerebellar cortex regions for experimental animals, and there are no studies for the mouse. Tracers Fluoro-Gold and cholera toxin B were injected into circumscribed regions of the cerebellar cortex, and retrogradely labeled spinal cord neurons were mapped throughout the spinal cord. Spinal projections to the cerebellar cortex were mainly from five neuronal columns—central cervical nucleus, dorsal nucleus, lumbar and sacral precerebellar nuclei, and lumbar border precerebellar cells—and from scattered neurons located in the deep dorsal horn and laminae 6-8. The spinocerebellar projections to the cortex were mainly to the vermis. All five precerebellar cell columns projected to both anterior and posterior parts of the cerebellar cortex. Results of this study provide an amendment to the known rostral and caudal boundaries of the precerebellar cell columns in the mouse. Scattered precerebellar neurons in the most caudal deep dorsal horn and laminae 6-8 projected exclusively to the anterior part of the cerebellar cortex. In this study, no labeled spinal neurons were found to project to the lobules 6 and 7 of the cerebellar vermis, the flocculus, and the paraflocculus. Spinocerebellar neurons were located bilaterally, but the majority of the projections were contralateral for the central cervical nucleus, and ipsilateral for the remaining spinal precerebellar neuronal clusters. Springer-Verlag Berlin Heidelberg, 2014 Spinal cord nationallicence Precerebellar nuclei nationallicence Cerebellar cortex nationallicence Vermis nationallicence 1-10Cb : Lobule 1-10 of the cerebellar vermis nationallicence 6-8Sp : Spinal laminae 6-8 nationallicence C : Cervical nationallicence CeCv : Central cervical nucleus nationallicence Co : Coccygeal nationallicence Cop : Copula of the pyramis nationallicence Crus1 : Crus1 of the ansiform lobule nationallicence Crus2 : Crus2 of the ansiform lobule nationallicence CTB : Cholera toxin B subunit nationallicence D : Dorsal nucleus nationallicence DDH : Deep dorsal horn nationallicence dsc : Dorsal spinocerebellar tract nationallicence FG : Fluoro-Gold nationallicence Fl : Flocculus nationallicence IntDL : Dorsolateral hump of the interposed cerebellar nucleus nationallicence L : Lumbar nationallicence LBPr : Lumbar border precerebellar cells nationallicence LPrCb : Lumbar precerebellar nucleus nationallicence PFl : Paraflocculus nationallicence PM : Paramedian lobule nationallicence S : Sacral nationallicence Sim : Simple lobule nationallicence SPrCb : Sacral precerebellar nucleus nationallicence T : Thoracic nationallicence vsc : Ventral spinocerebellar tract nationallicence Sengul Gulgun Department of Anatomy, School of Medicine, Ege University, 35100, Bornova, Izmir, Turkey aut Fu YuHong Neuroscience Research Australia, 2031, Sydney, NSW, Australia aut Yu You Neuroscience Research Australia, 2031, Sydney, NSW, Australia aut Paxinos George Neuroscience Research Australia, 2031, Sydney, NSW, Australia aut Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2997-3009 1863-2653 220:5<2997 2015 220 429 https://doi.org/10.1007/s00429-014-0840-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0840-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sengul Gulgun Department of Anatomy, School of Medicine, Ege University, 35100, Bornova, Izmir, Turkey aut NATIONALLICENCE 700 1- Fu YuHong Neuroscience Research Australia, 2031, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Yu You Neuroscience Research Australia, 2031, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Paxinos George Neuroscience Research Australia, 2031, Sydney, NSW, Australia aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2997-3009 1863-2653 220:5<2997 2015 220 429