caa a22 4500 606202854 CHVBK 20210128100955.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00429-014-0835-4 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0835-4 Magnified effects of the COMT gene on white-matter microstructure in very old age [Elektronische Daten] [Goran Papenberg, Martin Lövdén, Erika Laukka, Grégoria Kalpouzos, Lina Keller, Caroline Graff, Ylva Köhncke, Tie-Qiang Li, Laura Fratiglioni, Lars Bäckman] Genetic factors may partly account for between-person differences in brain integrity in old age. Evidence from human and animal studies suggests that the dopaminergic system is implicated in the modulation of white-matter integrity. We investigated whether a genetic variation in the Catechol-O-Methyltransferase (COMT) Val158Met polymorphism, which influences dopamine availability in prefrontal cortex, contributes to interindividual differences in white-matter microstructure, as measured with diffusion-tensor imaging. In a sample of older adults from a population-based study (60-87years; n=238), we found that the COMT polymorphism affects white-matter microstructure, indexed by fractional anisotropy and mean diffusivity, of several white-matter tracts in the oldest age group (81-87years), although there were no reliable associations between COMT and white-matter microstructure in the two younger age groups (60-66 and 72-78years). These findings extend previous observations of magnified genetic effects on cognition in old age to white-matter integrity. Springer-Verlag Berlin Heidelberg, 2014 Aging nationallicence COMT nationallicence Dopamine nationallicence DTI nationallicence White-matter integrity nationallicence Papenberg Goran Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden aut Lövdén Martin Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden aut Laukka Erika Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden aut Kalpouzos Grégoria Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden aut Keller Lina Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden aut Graff Caroline KI-Alzheimer Disease Research Center, Department NVS, Karolinska Institutet, Stockholm, Sweden aut Köhncke Ylva Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden aut Li Tie-Qiang Department of Medical Physics, Karolinska University Hospital, Stockholm, Sweden aut Fratiglioni Laura Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden aut Bäckman Lars Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden aut Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2927-2938 1863-2653 220:5<2927 2015 220 429 https://doi.org/10.1007/s00429-014-0835-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0835-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Papenberg Goran Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden aut NATIONALLICENCE 700 1- Lövdén Martin Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden aut NATIONALLICENCE 700 1- Laukka Erika Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden aut NATIONALLICENCE 700 1- Kalpouzos Grégoria Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden aut NATIONALLICENCE 700 1- Keller Lina Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden aut NATIONALLICENCE 700 1- Graff Caroline KI-Alzheimer Disease Research Center, Department NVS, Karolinska Institutet, Stockholm, Sweden aut NATIONALLICENCE 700 1- Köhncke Ylva Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden aut NATIONALLICENCE 700 1- Li Tie-Qiang Department of Medical Physics, Karolinska University Hospital, Stockholm, Sweden aut NATIONALLICENCE 700 1- Fratiglioni Laura Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden aut NATIONALLICENCE 700 1- Bäckman Lars Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2927-2938 1863-2653 220:5<2927 2015 220 429