caa a22 4500 606202862 CHVBK 20210128100955.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00429-014-0809-6 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0809-6 Connectivity-based parcellation of the human frontal polar cortex [Elektronische Daten] [Massieh Moayedi, Tim Salomons, Katharine Dunlop, Jonathan Downar, Karen Davis] The frontal pole corresponds to Brodmann area (BA) 10, the largest single architectonic area in the human frontal lobe. Generally, BA10 is thought to contain two or three subregions that subserve broad functions such as multitasking, social cognition, attention, and episodic memory. However, there is a substantial debate about the functional and structural heterogeneity of this large frontal region. Previous connectivity-based parcellation studies have identified two or three subregions in the human frontal pole. Here, we used diffusion tensor imaging to assess structural connectivity of BA10 in 35 healthy subjects and delineated subregions based on this connectivity. This allowed us to determine the correspondence of structurally based subregions with the scheme previously defined functionally. Three subregions could be defined in each subject. However, these three subregions were not spatially consistent between subjects. Therefore, we accepted a solution with two subregions that encompassed the lateral and medial frontal pole. We then examined resting-state functional connectivity of the two subregions and found significant differences between their connectivities. The medial cluster was connected to nodes of the default-mode network, which is implicated in internally focused, self-related thought, and social cognition. The lateral cluster was connected to nodes of the executive control network, associated with directed attention and working memory. These findings support the concept that there are two major anatomical subregions of the frontal pole related to differences in functional connectivity. The Author(s), 2014 Diffusion MRI nationallicence BA10 nationallicence White matter nationallicence Anatomy nationallicence Frontal lobe nationallicence Moayedi Massieh Institute of Medical Science, University of Toronto, M5S 1A8, Toronto, Canada aut Salomons Tim Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Room MP14-306, M5T 2S8, Toronto, ON, Canada aut Dunlop Katharine Department of Psychiatry, University Health Network, M5T 2S8, Toronto, Canada aut Downar Jonathan Department of Psychiatry, University Health Network, M5T 2S8, Toronto, Canada aut Davis Karen Institute of Medical Science, University of Toronto, M5S 1A8, Toronto, Canada aut Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2603-2616 1863-2653 220:5<2603 2015 220 429 https://doi.org/10.1007/s00429-014-0809-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0809-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moayedi Massieh Institute of Medical Science, University of Toronto, M5S 1A8, Toronto, Canada aut NATIONALLICENCE 700 1- Salomons Tim Division of Brain, Imaging and Behaviour-Systems Neuroscience, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Room MP14-306, M5T 2S8, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Dunlop Katharine Department of Psychiatry, University Health Network, M5T 2S8, Toronto, Canada aut NATIONALLICENCE 700 1- Downar Jonathan Department of Psychiatry, University Health Network, M5T 2S8, Toronto, Canada aut NATIONALLICENCE 700 1- Davis Karen Institute of Medical Science, University of Toronto, M5S 1A8, Toronto, Canada aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2603-2616 1863-2653 220:5<2603 2015 220 429