caa a22 4500 606202900 CHVBK 20210128100955.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00429-014-0961-z doi (NATIONALLICENCE)springer-10.1007/s00429-014-0961-z From genes to folds: a review of cortical gyrification theory [Elektronische Daten] [Lisa Ronan, Paul Fletcher] Cortical gyrification is not a random process. Instead, the folds that develop are synonymous with the functional organization of the cortex, and form patterns that are remarkably consistent across individuals and even some species. How this happens is not well understood. Although many developmental features and evolutionary adaptations have been proposed as the primary cause of gyrencephaly, it is not evident that gyrification is reducible in this way. In recent years, we have greatly increased our understanding of the multiple factors that influence cortical folding, from the action of genes in health and disease to evolutionary adaptations that characterize distinctions between gyrencephalic and lissencephalic cortices. Nonetheless it is unclearhow these factors which influence events at a small-scale synthesize to form the consistent and biologically meaningful large-scale features of sulci and gyri. In this article, we review the empirical evidence which suggests that gyrification is the product of a generalized mechanism, namely the differential expansion of the cortex. By considering the implications of this model, we demonstrate that it is possible to link the fundamental biological components of the cortex to its large-scale pattern-specific morphology and functional organization. The Author(s), 2014 Gyrification nationallicence Morphology nationallicence Cerebral cortex nationallicence Tangential expansion nationallicence Ronan Lisa Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Sir William Hardy Building, Downing Site, Downing Street, CB2 3EB, Cambridge, UK aut Fletcher Paul Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Sir William Hardy Building, Downing Site, Downing Street, CB2 3EB, Cambridge, UK aut Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2475-2483 1863-2653 220:5<2475 2015 220 429 https://doi.org/10.1007/s00429-014-0961-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0961-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ronan Lisa Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Sir William Hardy Building, Downing Site, Downing Street, CB2 3EB, Cambridge, UK aut NATIONALLICENCE 700 1- Fletcher Paul Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Sir William Hardy Building, Downing Site, Downing Street, CB2 3EB, Cambridge, UK aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2475-2483 1863-2653 220:5<2475 2015 220 429