caa a22 4500 606202919 CHVBK 20210128100955.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00429-014-0808-7 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0808-7 Eye position modulates retinotopic responses in early visual areas: a bias for the straight-ahead direction [Elektronische Daten] [Francesca Strappini, Sabrina Pitzalis, Abraham Snyder, Mark McAvoy, Martin Sereno, Maurizio Corbetta, Gordon Shulman] Even though the eyes constantly change position, the location of a stimulus can be accurately represented by a population of neurons with retinotopic receptive fields modulated by eye position gain fields. Recent electrophysiological studies, however, indicate that eye position gain fields may serve an additional function since they have a non-uniform spatial distribution that increases the neural response to stimuli in the straight-ahead direction. We used functional magnetic resonance imaging and a wide-field stimulus display to determine whether gaze modulations in early human visual cortex enhance the blood-oxygenation-level dependent (BOLD) response to stimuli that are straight-ahead. Subjects viewed rotating polar angle wedge stimuli centered straight-ahead or vertically displaced by ±20° eccentricity. Gaze position did not affect the topography of polar phase-angle maps, confirming that coding was retinotopic, but did affect the amplitude of the BOLD response, consistent with a gain field. In agreement with recent electrophysiological studies, BOLD responses in V1 and V2 to a wedge stimulus at a fixed retinal locus decreased when the wedge location in head-centered coordinates was farther from the straight-ahead direction. We conclude that stimulus-evoked BOLD signals are modulated by a systematic, non-uniform distribution of eye-position gain fields. The Author(s), 2014 Gain field nationallicence Gaze nationallicence Retinotopy nationallicence Vertical meridian nationallicence Wide-field nationallicence Strappini Francesca Department of Neurology, Washington University, School of Medicine, 63110, Saint Louis, MO, USA aut Pitzalis Sabrina Neuropsychology Research Centre, Scientific Institute for Research, Hospitalization, and Health Care (IRCCS, Istituto di Ricovero e Cura a Carattere Scientifico), Fondazione Santa Lucia, 00179, Rome, Italy aut Snyder Abraham Department of Radiology, Washington University, School of Medicine, 63110, Saint Louis, MO, USA aut McAvoy Mark Department of Radiology, Washington University, School of Medicine, 63110, Saint Louis, MO, USA aut Sereno Martin Birkbeck-UCL Centre for NeuroImaging, WC1H 0AP, London, UK aut Corbetta Maurizio Department of Neurology, Washington University, School of Medicine, 63110, Saint Louis, MO, USA aut Shulman Gordon Department of Neurology, Washington University, School of Medicine, 63110, Saint Louis, MO, USA aut Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2587-2601 1863-2653 220:5<2587 2015 220 429 https://doi.org/10.1007/s00429-014-0808-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0808-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Strappini Francesca Department of Neurology, Washington University, School of Medicine, 63110, Saint Louis, MO, USA aut NATIONALLICENCE 700 1- Pitzalis Sabrina Neuropsychology Research Centre, Scientific Institute for Research, Hospitalization, and Health Care (IRCCS, Istituto di Ricovero e Cura a Carattere Scientifico), Fondazione Santa Lucia, 00179, Rome, Italy aut NATIONALLICENCE 700 1- Snyder Abraham Department of Radiology, Washington University, School of Medicine, 63110, Saint Louis, MO, USA aut NATIONALLICENCE 700 1- McAvoy Mark Department of Radiology, Washington University, School of Medicine, 63110, Saint Louis, MO, USA aut NATIONALLICENCE 700 1- Sereno Martin Birkbeck-UCL Centre for NeuroImaging, WC1H 0AP, London, UK aut NATIONALLICENCE 700 1- Corbetta Maurizio Department of Neurology, Washington University, School of Medicine, 63110, Saint Louis, MO, USA aut NATIONALLICENCE 700 1- Shulman Gordon Department of Neurology, Washington University, School of Medicine, 63110, Saint Louis, MO, USA aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2587-2601 1863-2653 220:5<2587 2015 220 429