caa a22 4500 606202935 CHVBK 20210128100955.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00429-014-0799-4 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0799-4 Extrastriate projections in human optic radiation revealed by fMRI-informed tractography [Elektronische Daten] [Ivan Alvarez, D. Schwarzkopf, Chris Clark] The human optic radiation (OR) is the main pathway for conveying visual input to occipital cortex, but it is unclear whether it projects beyond primary visual cortex (V1). In this study, we used functional MRI mapping to delineate early visual areas in 30 healthy volunteers and determined the termination area of the OR as reconstructed with diffusion tractography. Direct thalamo-cortical projections to areas V2 and V3 were found in all hemispheres tested, with a distinct anatomical arrangement of superior-inferior fiber placement for dorsal and ventral projections, respectively, and a medio-lateral nesting arrangement for projections to V1, V2 and V3. Finally, segment-specific microstructure was examined, revealing sub-fascicular information. This is to date the first in vivo demonstration of direct extrastriate projections of the OR in humans. The Author(s), 2014 Optic radiation nationallicence Visual pathways nationallicence Extrastriate nationallicence fMRI nationallicence Diffusion tensor imaging nationallicence Tractography nationallicence Alvarez Ivan Institute of Child Health, University College London, WC1N 1EH, London, UK aut Schwarzkopf D. Cognitive, Perceptual and Brain Sciences, University College London, WC1H 0AP, London, UK aut Clark Chris Institute of Child Health, University College London, WC1N 1EH, London, UK aut Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2519-2532 1863-2653 220:5<2519 2015 220 429 https://doi.org/10.1007/s00429-014-0799-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0799-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Alvarez Ivan Institute of Child Health, University College London, WC1N 1EH, London, UK aut NATIONALLICENCE 700 1- Schwarzkopf D. Cognitive, Perceptual and Brain Sciences, University College London, WC1H 0AP, London, UK aut NATIONALLICENCE 700 1- Clark Chris Institute of Child Health, University College London, WC1N 1EH, London, UK aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2519-2532 1863-2653 220:5<2519 2015 220 429