caa a22 4500 606202978 CHVBK 20210128100955.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00429-014-0796-7 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0796-7 Decision making in avoidance-reward conflict: a paradigm for non-human primates and humans [Elektronische Daten] [Demetrio Sierra-Mercado, Thilo Deckersbach, Amanda Arulpragasam, Tina Chou, Alexandra Rodman, Amanda Duffy, Eric McDonald, Christine Eckhardt, Andrew Corse, Navneet Kaur, Emad Eskandar, Darin Dougherty] Decision making in both animals and humans is influenced by the anticipation of reward and/or punishment. Little is known about how reward and punishment interact in the context of decision making. The Avoidance-Reward Conflict (ARC) Task is a new paradigm that varies the degree of reward and the probability of punishment in a single paradigm that can be used in both non-human primates (NHPs) and humans. This study examined the behavioral pattern in the ARC task in both NHPs and humans. Two adult male NHPs (macaca mulatta) and 20 healthy human volunteers (12 females) participated in the ARC task. NHPs and humans perform similarly on the ARC task. With a high probability of punishment (an aversive air puff to the eye), both NHPs and humans are more likely to forgo reward if it is small or medium magnitude than when it is large. Both NHPs and humans perform similarly on the same behavioral task suggesting the reliability of animal models in predicting human behavior. Springer-Verlag Berlin Heidelberg, 2014 Anxiety nationallicence Animal model nationallicence Obsessive-compulsive disorder (OCD) nationallicence Bipolar disorder nationallicence Sierra-Mercado Demetrio Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 02114, Boston, MA, USA aut Deckersbach Thilo Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, 02129, Charlestown, MA, USA aut Arulpragasam Amanda Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, 02129, Charlestown, MA, USA aut Chou Tina Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, 02129, Charlestown, MA, USA aut Rodman Alexandra Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, 02129, Charlestown, MA, USA aut Duffy Amanda Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, 02129, Charlestown, MA, USA aut McDonald Eric Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 02114, Boston, MA, USA aut Eckhardt Christine Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 02114, Boston, MA, USA aut Corse Andrew Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, 02129, Charlestown, MA, USA aut Kaur Navneet Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, 02129, Charlestown, MA, USA aut Eskandar Emad Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 02114, Boston, MA, USA aut Dougherty Darin Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, 02129, Charlestown, MA, USA aut Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2509-2517 1863-2653 220:5<2509 2015 220 429 https://doi.org/10.1007/s00429-014-0796-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0796-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sierra-Mercado Demetrio Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Deckersbach Thilo Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, 02129, Charlestown, MA, USA aut NATIONALLICENCE 700 1- Arulpragasam Amanda Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, 02129, Charlestown, MA, USA aut NATIONALLICENCE 700 1- Chou Tina Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, 02129, Charlestown, MA, USA aut NATIONALLICENCE 700 1- Rodman Alexandra Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, 02129, Charlestown, MA, USA aut NATIONALLICENCE 700 1- Duffy Amanda Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, 02129, Charlestown, MA, USA aut NATIONALLICENCE 700 1- McDonald Eric Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Eckhardt Christine Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Corse Andrew Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, 02129, Charlestown, MA, USA aut NATIONALLICENCE 700 1- Kaur Navneet Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, 02129, Charlestown, MA, USA aut NATIONALLICENCE 700 1- Eskandar Emad Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Dougherty Darin Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, 02129, Charlestown, MA, USA aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2509-2517 1863-2653 220:5<2509 2015 220 429