caa a22 4500 606203001 CHVBK 20210128100955.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00429-014-0834-5 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0834-5 Tangential migratory pathways of subpallial origin in the embryonic telencephalon of sharks: evolutionary implications [Elektronische Daten] [Idoia Quintana-Urzainqui, Isabel Rodríguez-Moldes, Sylvie Mazan, Eva Candal] Tangential neuronal migration occurs along different axes from the axis demarcated by radial glia and it is thought to have evolved as a mechanism to increase the diversity of cell types in brain areas, which in turn resulted in increased complexity of functional networks. In the telencephalon of amniotes, different embryonic tangential pathways have been characterized. However, little is known about the exact routes of migrations in basal vertebrates. Cartilaginous fishes occupy a key phylogenetic position to assess the ancestral condition of vertebrate brain organization. In order to identify putative subpallial-derived tangential migratory pathways in the telencephalon of sharks, we performed a detailed analysis of the distribution pattern of GAD and Dlx2, two reliable markers of tangentially migrating interneurons of subpallial origin in the developing forebrain. We propose the existence of five tangential routes directed toward different telencephalic regions. We conclude that four of the five routes might have emerged in the common ancestor of jawed vertebrates. We have paid special attention to the characterization of the proposed migratory pathway directed towards the olfactory bulbs. Our results suggest that it may be equivalent to the "rostral migratory stream” of mammals and led us to propose a hypothesis about its evolution. The analysis of the final destinations of two other streams allowed us to identify the putative dorsal and medial pallium of sharks, the regions from which the neocortex and hippocampus might have, respectively, evolved. Derived features were also reported and served to explain some distinctive traits in the morphology of the telencephalon of cartilaginous fishes. Springer-Verlag Berlin Heidelberg, 2014 Tangential migrations nationallicence Ganglionic eminences nationallicence Dlx2 nationallicence GAD nationallicence Evolution nationallicence Rostral migratory stream nationallicence Cb : Cerebellum nationallicence Di : Diencephalon nationallicence Glom : Glomerulus nationallicence LGE-h : Lateral ganglionic eminence homolog nationallicence LS : Lateral stream nationallicence Mes : Mesencephalon nationallicence MGE-h : Medial ganglionic eminence homolog nationallicence MS : Medial stream nationallicence MP : Medial pallium nationallicence OB : Olfactory bulb nationallicence OT : Optic tectum nationallicence P : Pallium nationallicence Rh : Rhombencephalon nationallicence RS : Rostral stream nationallicence Sp : Subpallium nationallicence Tel : Telencephalon nationallicence V : Ventricle nationallicence Quintana-Urzainqui Idoia Departamento de Biología Celular y Ecología, Edificio CIBUS, Campus Vida, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain aut Rodríguez-Moldes Isabel Departamento de Biología Celular y Ecología, Edificio CIBUS, Campus Vida, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain aut Mazan Sylvie UMR7150, UPMC Université Paris 6, CNRS, Université Européenne de Bretagne, UMR 7150, SBR, Roscoff, France aut Candal Eva Departamento de Biología Celular y Ecología, Edificio CIBUS, Campus Vida, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain aut Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2905-2926 1863-2653 220:5<2905 2015 220 429 https://doi.org/10.1007/s00429-014-0834-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0834-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Quintana-Urzainqui Idoia Departamento de Biología Celular y Ecología, Edificio CIBUS, Campus Vida, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain aut NATIONALLICENCE 700 1- Rodríguez-Moldes Isabel Departamento de Biología Celular y Ecología, Edificio CIBUS, Campus Vida, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain aut NATIONALLICENCE 700 1- Mazan Sylvie UMR7150, UPMC Université Paris 6, CNRS, Université Européenne de Bretagne, UMR 7150, SBR, Roscoff, France aut NATIONALLICENCE 700 1- Candal Eva Departamento de Biología Celular y Ecología, Edificio CIBUS, Campus Vida, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2905-2926 1863-2653 220:5<2905 2015 220 429