caa a22 4500 606203036 CHVBK 20210128105229.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00429-014-0804-y doi (NATIONALLICENCE)springer-10.1007/s00429-014-0804-y Grey matter volumetric changes related to recovery from hand paresis after cortical sensorimotor stroke [Elektronische Daten] [E. Abela, A. Seiler, J. Missimer, A. Federspiel, C. Hess, M. Sturzenegger, B. Weder, R. Wiest] Preclinical studies using animal models have shown that grey matter plasticity in both perilesional and distant neural networks contributes to behavioural recovery of sensorimotor functions after ischaemic cortical stroke. Whether such morphological changes can be detected after human cortical stroke is not yet known, but this would be essential to better understand post-stroke brain architecture and its impact on recovery. Using serial behavioural and high-resolution magnetic resonance imaging (MRI) measurements, we tracked recovery of dexterous hand function in 28 patients with ischaemic stroke involving the primary sensorimotor cortices. We were able to classify three recovery subgroups (fast, slow, and poor) using response feature analysis of individual recovery curves. To detect areas with significant longitudinal grey matter volume (GMV) change, we performed tensor-based morphometry of MRI data acquired in the subacute phase, i.e. after the stage compromised by acute oedema and inflammation. We found significant GMV expansion in the perilesional premotor cortex, ipsilesional mediodorsal thalamus, and caudate nucleus, and GMV contraction in the contralesional cerebellum. According to an interaction model, patients with fast recovery had more perilesional than subcortical expansion, whereas the contrary was true for patients with impaired recovery. Also, there were significant voxel-wise correlations between motor performance and ipsilesional GMV contraction in the posterior parietal lobes and expansion in dorsolateral prefrontal cortex. In sum, perilesional GMV expansion is associated with successful recovery after cortical stroke, possibly reflecting the restructuring of local cortical networks. Distant changes within the prefrontal-striato-thalamic network are related to impaired recovery, probably indicating higher demands on cognitive control of motor behaviour. The Author(s), 2014 Cortical stroke nationallicence Grey matter plasticity nationallicence Tensor-based morphometry nationallicence Motor recovery nationallicence Abela E. Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, University Hospital Inselspital and University of Bern, Bern, Switzerland aut Seiler A. Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, University Hospital Inselspital and University of Bern, Bern, Switzerland aut Missimer J. Laboratory of Biomolecular Research, Paul Scherrer Institute, Villigen, Switzerland aut Federspiel A. Department of Psychiatric Neurophysiology, University Hospital of Psychiatry and University of Bern, Bern, Switzerland aut Hess C. Department of Neurology, University Hospital Inselspital and University of Bern, Bern, Switzerland aut Sturzenegger M. Department of Neurology, University Hospital Inselspital and University of Bern, Bern, Switzerland aut Weder B. Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, University Hospital Inselspital and University of Bern, Bern, Switzerland aut Wiest R. Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, University Hospital Inselspital and University of Bern, Bern, Switzerland aut Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2533-2550 1863-2653 220:5<2533 2015 220 429 https://doi.org/10.1007/s00429-014-0804-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0804-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abela E. Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, University Hospital Inselspital and University of Bern, Bern, Switzerland aut NATIONALLICENCE 700 1- Seiler A. Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, University Hospital Inselspital and University of Bern, Bern, Switzerland aut NATIONALLICENCE 700 1- Missimer J. Laboratory of Biomolecular Research, Paul Scherrer Institute, Villigen, Switzerland aut NATIONALLICENCE 700 1- Federspiel A. Department of Psychiatric Neurophysiology, University Hospital of Psychiatry and University of Bern, Bern, Switzerland aut NATIONALLICENCE 700 1- Hess C. Department of Neurology, University Hospital Inselspital and University of Bern, Bern, Switzerland aut NATIONALLICENCE 700 1- Sturzenegger M. Department of Neurology, University Hospital Inselspital and University of Bern, Bern, Switzerland aut NATIONALLICENCE 700 1- Weder B. Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, University Hospital Inselspital and University of Bern, Bern, Switzerland aut NATIONALLICENCE 700 1- Wiest R. Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, University Hospital Inselspital and University of Bern, Bern, Switzerland aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2533-2550 1863-2653 220:5<2533 2015 220 429 SWISSBIB 335508219