caa a22 4500 606203052 CHVBK 20210128100956.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00429-014-0817-6 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0817-6 Volume of the hippocampal subfields in healthy adults: differential associations with age and a pro-inflammatory genetic variant [Elektronische Daten] [Naftali Raz, Ana Daugherty, Andrew Bender, Cheryl Dahle, Susan Land] The hippocampus is one of the most age-sensitive brain regions, yet the mechanisms of hippocampal shrinkage remain unclear. Recent studies suggest that hippocampal subfields are differentially vulnerable to aging and differentially sensitive to vascular risk. Promoters of inflammation are frequently proposed as major contributors to brain aging and vascular disease but their effects on hippocampal subfields are unknown. We examined the associations of hippocampal subfield volumes with age, a vascular risk factor (hypertension), and genetic polymorphisms associated with variation in pro-inflammatory cytokines levels (IL-1β C-511T and IL-6 C-174G) and risk for Alzheimer's disease (APOEε4) in healthy adult volunteers (N=80; age=22-82years). Volumes of three hippocampal subfields, cornu ammonis (CA) 1-2, CA3-dentate gyrus, and the subiculum were manually measured on high-resolution magnetic resonance images. Advanced age was differentially associated with smaller volume of CA1-2, whereas carriers of the T allele of IL-1β C-511T polymorphism had smaller volume of all hippocampal subfields than CC homozygotes did. Neither of the other genetic variants, nor diagnosis of hypertension, was associated with any of the measured volumes. The results support the notion that volumes of age-sensitive brain regions may be affected by pro-inflammatory factors that may be targeted by therapeutic interventions. Springer-Verlag Berlin Heidelberg, 2014 Brain nationallicence IL-1beta nationallicence IL-6 nationallicence CA1 nationallicence APOE nationallicence Hypertension nationallicence Raz Naftali Department of Psychology and Institute of Gerontology, Wayne State University, 87 E. Ferry St., 226 Knapp Building, 48202, Detroit, MI, USA aut Daugherty Ana Department of Psychology and Institute of Gerontology, Wayne State University, 87 E. Ferry St., 226 Knapp Building, 48202, Detroit, MI, USA aut Bender Andrew Institute of Gerontology, Wayne State University, 87 E. Ferry St., 226 Knapp Building, 48202, Detroit, MI, USA aut Dahle Cheryl Institute of Gerontology, Wayne State University, 87 E. Ferry St., 226 Knapp Building, 48202, Detroit, MI, USA aut Land Susan Department of Obstetrics and Gynecology, Wayne State University, 275 East Hancock, C.S. Mott Center, 48201, Detroit, MI, USA aut Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2663-2674 1863-2653 220:5<2663 2015 220 429 https://doi.org/10.1007/s00429-014-0817-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0817-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Raz Naftali Department of Psychology and Institute of Gerontology, Wayne State University, 87 E. Ferry St., 226 Knapp Building, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- Daugherty Ana Department of Psychology and Institute of Gerontology, Wayne State University, 87 E. Ferry St., 226 Knapp Building, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- Bender Andrew Institute of Gerontology, Wayne State University, 87 E. Ferry St., 226 Knapp Building, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- Dahle Cheryl Institute of Gerontology, Wayne State University, 87 E. Ferry St., 226 Knapp Building, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- Land Susan Department of Obstetrics and Gynecology, Wayne State University, 275 East Hancock, C.S. Mott Center, 48201, Detroit, MI, USA aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2663-2674 1863-2653 220:5<2663 2015 220 429