caa a22 4500 606203109 CHVBK 20210128100956.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00429-014-0795-8 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0795-8 Toward neurobiological characterization of functional homogeneity in the human cortex: regional variation, morphological association and functional covariance network organization [Elektronische Daten] [Lili Jiang, Ting Xu, Ye He, Xiao-Hui Hou, Jinhui Wang, Xiao-Yan Cao, Gao-Xia Wei, Zhi Yang, Yong He, Xi-Nian Zuo] Local functional homogeneity of the human cortex indicates the boundaries between functionally heterogeneous regions and varies remarkably across the cortical mantle. It is unclear whether these variations have the neurobiological and structural basis. We employed structural and resting-state functional magnetic resonance imaging scans from 482 healthy subjects and computed the vertex-wise regional homogeneity of low-frequency fluctuations (2dReHo) and five measures of cortical morphology. We then used these metrics to examine regional variation, morphological association and functional covariance network of 2dReHo. Within the ventral visual stream, increases of 2dReHo reflect reduced complexity of information processing or functional hierarchies. Along the divisions of the prefrontal cortex and posteromedial cortex, the gradients of 2dReHo revealed the hierarchical organization within the two association areas, respectively. Individual differences in 2dReHo are associated with those of cortical morphology, and their whole-brain inter-regional covariation is organized into a functional covariance network, comprising five hierarchically organized modules with hubs of both primary sensory and high-order association areas. These highly reproducible observations suggest that local functional homogeneity has neurobiological relevance that is likely determined by anatomical, developmental and neurocognitive factors and should serve as a neuroimaging marker to investigate the human brain function. Springer-Verlag Berlin Heidelberg, 2014 Functional homogeneity nationallicence Prefrontal cortex nationallicence Posteromedial cortex nationallicence Functional hierarchy nationallicence Structural morphometry nationallicence Functional covariance nationallicence Network nationallicence Jiang Lili Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Room 708, Southern Building, No. 16 Lincui Road, Chaoyang District, 100101, Beijing, China aut Xu Ting Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Room 708, Southern Building, No. 16 Lincui Road, Chaoyang District, 100101, Beijing, China aut He Ye Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Room 708, Southern Building, No. 16 Lincui Road, Chaoyang District, 100101, Beijing, China aut Hou Xiao-Hui Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Room 708, Southern Building, No. 16 Lincui Road, Chaoyang District, 100101, Beijing, China aut Wang Jinhui Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, 310036, Hangzhou, Zhejiang, China aut Cao Xiao-Yan Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Room 708, Southern Building, No. 16 Lincui Road, Chaoyang District, 100101, Beijing, China aut Wei Gao-Xia Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Room 708, Southern Building, No. 16 Lincui Road, Chaoyang District, 100101, Beijing, China aut Yang Zhi Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Room 708, Southern Building, No. 16 Lincui Road, Chaoyang District, 100101, Beijing, China aut He Yong State Key Laboratory of Cognitive Neuroscience and Learning and International Data Group/McGovern Institute for Brain Research, Beijing Normal University, 100087, Beijing, China aut Zuo Xi-Nian Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Room 708, Southern Building, No. 16 Lincui Road, Chaoyang District, 100101, Beijing, China aut Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2485-2507 1863-2653 220:5<2485 2015 220 429 https://doi.org/10.1007/s00429-014-0795-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0795-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jiang Lili Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Room 708, Southern Building, No. 16 Lincui Road, Chaoyang District, 100101, Beijing, China aut NATIONALLICENCE 700 1- Xu Ting Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Room 708, Southern Building, No. 16 Lincui Road, Chaoyang District, 100101, Beijing, China aut NATIONALLICENCE 700 1- He Ye Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Room 708, Southern Building, No. 16 Lincui Road, Chaoyang District, 100101, Beijing, China aut NATIONALLICENCE 700 1- Hou Xiao-Hui Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Room 708, Southern Building, No. 16 Lincui Road, Chaoyang District, 100101, Beijing, China aut NATIONALLICENCE 700 1- Wang Jinhui Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, 310036, Hangzhou, Zhejiang, China aut NATIONALLICENCE 700 1- Cao Xiao-Yan Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Room 708, Southern Building, No. 16 Lincui Road, Chaoyang District, 100101, Beijing, China aut NATIONALLICENCE 700 1- Wei Gao-Xia Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Room 708, Southern Building, No. 16 Lincui Road, Chaoyang District, 100101, Beijing, China aut NATIONALLICENCE 700 1- Yang Zhi Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Room 708, Southern Building, No. 16 Lincui Road, Chaoyang District, 100101, Beijing, China aut NATIONALLICENCE 700 1- He Yong State Key Laboratory of Cognitive Neuroscience and Learning and International Data Group/McGovern Institute for Brain Research, Beijing Normal University, 100087, Beijing, China aut NATIONALLICENCE 700 1- Zuo Xi-Nian Laboratory for Functional Connectome and Development, Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Room 708, Southern Building, No. 16 Lincui Road, Chaoyang District, 100101, Beijing, China aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2485-2507 1863-2653 220:5<2485 2015 220 429