caa a22 4500 606203133 CHVBK 20210128100956.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00429-014-0826-5 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0826-5 Reduced density of geniculocortical terminals in foveal layer 4A in the macaque primary visual cortex: relationship to S-cone density [Elektronische Daten] [Virginia Garcia-Marin, Marina Sundiang, Michael Hawken] The S-cone system is closely linked to the perception of blue/yellow. The trichromatic system of Old-World monkeys and humans has relatively few S-cones in the fovea. In this study, we investigated the distribution of putative S-cone afferents in macaques primary visual cortex (V1) which form a characteristic honeycomb arrangement in layer 4A. It was hypothesized that if there were a low number of S-cone opponent projecting neurons in central vision then this would be seen as a reduction in afferents in foveal layer 4A. Recent studies have shown that the vesicular glutamate transporter 2 (VGlut2) is a marker for thalamic afferent terminals in cortex. The distribution of VGlut2-immunoreactive (-ir) terminals was studied in the foveal and perifoveal representation of V1. It was found that there was a substantial reduction in the terminal density in the foveal representation: the density was 5-6 times lower in the foveal V1 than in regions representing perifoveal eccentricities of 1°-2° and beyond. These findings may provide the cortical substrate of foveal tritanopia, the reduced blue perceptual ability for small fields in the center of gaze. Springer-Verlag Berlin Heidelberg, 2014 Thalamic afferents nationallicence Visual cortex nationallicence S-cones nationallicence Vesicular glutamate transporter nationallicence Macaque nationallicence Garcia-Marin Virginia Center for Neural Science, New York University, 4 Washington Place, 10003, New York, NY, USA aut Sundiang Marina Center for Neural Science, New York University, 4 Washington Place, 10003, New York, NY, USA aut Hawken Michael Center for Neural Science, New York University, 4 Washington Place, 10003, New York, NY, USA aut Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2783-2796 1863-2653 220:5<2783 2015 220 429 https://doi.org/10.1007/s00429-014-0826-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0826-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Garcia-Marin Virginia Center for Neural Science, New York University, 4 Washington Place, 10003, New York, NY, USA aut NATIONALLICENCE 700 1- Sundiang Marina Center for Neural Science, New York University, 4 Washington Place, 10003, New York, NY, USA aut NATIONALLICENCE 700 1- Hawken Michael Center for Neural Science, New York University, 4 Washington Place, 10003, New York, NY, USA aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2783-2796 1863-2653 220:5<2783 2015 220 429