caa a22 4500 606203141 CHVBK 20210128100956.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00429-014-0815-8 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0815-8 The superior paraolivary nucleus shapes temporal response properties of neurons in the inferior colliculus [Elektronische Daten] [Richard Felix II, Anna Magnusson, Albert Berrebi] The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route to the cortex. Neurons in the SPON and IC exhibit highly precise responses to temporal sound features, which are important perceptual cues for naturally occurring sounds. To determine how inhibitory input from the SPON contributes to the encoding of temporal information in the IC, a reversible inactivation procedure was conducted to silence SPON neurons, while recording responses to amplitude-modulated tones and silent gaps between tones in the IC. The results show that SPON-derived inhibition shapes responses of onset and sustained units in the IC via different mechanisms. Onset neurons appear to be driven primarily by excitatory inputs and their responses are shaped indirectly by SPON-derived inhibition, whereas sustained neurons are heavily influenced directly by transient offset inhibition from the SPON. The findings also demonstrate that a more complete dissection of temporal processing pathways is critical for understanding how biologically important sounds are encoded by the brain. Springer-Verlag Berlin Heidelberg, 2014 Amplitude modulation nationallicence Gap detection nationallicence Superior olive nationallicence Sound envelopes nationallicence Temporal processing nationallicence Felix II Richard Department of Otolaryngology-Head and Neck Surgery and the Sensory Neuroscience Research Center, HSC, West Virginia University School of Medicine, PO Box 9303, 26506-9303, Morgantown, WV, USA aut Magnusson Anna Department of Clinical Science, Intervention and Technology, Center for Hearing and Communication Research, Karolinska Institutet, Karolinska University Hospital, 17176, Stockholm, Sweden aut Berrebi Albert Department of Otolaryngology-Head and Neck Surgery and the Sensory Neuroscience Research Center, HSC, West Virginia University School of Medicine, PO Box 9303, 26506-9303, Morgantown, WV, USA aut Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2639-2652 1863-2653 220:5<2639 2015 220 429 https://doi.org/10.1007/s00429-014-0815-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0815-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Felix II Richard Department of Otolaryngology-Head and Neck Surgery and the Sensory Neuroscience Research Center, HSC, West Virginia University School of Medicine, PO Box 9303, 26506-9303, Morgantown, WV, USA aut NATIONALLICENCE 700 1- Magnusson Anna Department of Clinical Science, Intervention and Technology, Center for Hearing and Communication Research, Karolinska Institutet, Karolinska University Hospital, 17176, Stockholm, Sweden aut NATIONALLICENCE 700 1- Berrebi Albert Department of Otolaryngology-Head and Neck Surgery and the Sensory Neuroscience Research Center, HSC, West Virginia University School of Medicine, PO Box 9303, 26506-9303, Morgantown, WV, USA aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2639-2652 1863-2653 220:5<2639 2015 220 429