caa a22 4500 606203168 CHVBK 20210128100956.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00429-014-0838-1 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0838-1 Multiscale fingerprinting of neuronal functional connectivity [Elektronische Daten] [Gang Song, Chung Tin, Chi-Sang Poon] Current cellular-based connectomics approaches aim to delineate the functional or structural organizations of mammalian brain circuits through neuronal activity mapping and/or axonal tracing. To discern possible connectivity between functionally identified neurons in widely distributed brain circuits, reliable and efficient network-based approaches of cross-registering or cross-correlating such functional-structural data are essential. Here, a novel cross-correlation approach that exploits multiple timing-specific, response-specific, and cell-specific neuronal characteristics as coincident fingerprint markers at the systems, network, and cellular levels is proposed. Application of this multiscale temporal-cellular coincident fingerprinting assay to the respiratory central pattern generator network in rats revealed a descending excitatory pathway with characteristic activity pattern and projecting from a distinct neuronal population in pons to its counterparts in medulla that control the post-inspiratory phase of the respiratory rhythm important for normal breathing, airway protection, and respiratory-vocalization coordination. This enabling neurotracing approach may prove valuable for functional connectivity mapping of other brain circuits. Springer-Verlag Berlin Heidelberg, 2014 Multiscale fingerprinting nationallicence Functional connectivity nationallicence Pneumotaxic center nationallicence Kölliker-Fuse nucleus nationallicence Pons nationallicence Post-inspiratory activity nationallicence Respiratory rhythm nationallicence Laryngeal motoneurons nationallicence Song Gang Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut Tin Chung Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut Poon Chi-Sang Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2967-2982 1863-2653 220:5<2967 2015 220 429 https://doi.org/10.1007/s00429-014-0838-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0838-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Song Gang Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut NATIONALLICENCE 700 1- Tin Chung Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut NATIONALLICENCE 700 1- Poon Chi-Sang Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/5(2015-09-01), 2967-2982 1863-2653 220:5<2967 2015 220 429