caa a22 4500 606203214 CHVBK 20210128100956.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00429-014-0706-z doi (NATIONALLICENCE)springer-10.1007/s00429-014-0706-z Disrupted brain anatomical connectivity in medication-naïve patients with first-episode schizophrenia [Elektronische Daten] [Ruibin Zhang, Qinling Wei, Zhuang Kang, Andrew Zalesky, Meng Li, Yong Xu, Leijun Li, Junjing Wang, Liangrong Zheng, Bin Wang, Jingping Zhao, Jinbei Zhang, Ruiwang Huang] Previous studies suggested that the topological properties of brain anatomical networks may be aberrant in schizophrenia (SCZ), and most of them focused on the chronic and antipsychotic-medicated SCZ patients which may introduce various confounding factors due to antipsychotic medication and duration of illness. To avoid those potential confounders, a desirable approach is to select medication-naïve, first-episode schizophrenia (FE-SCZ) patients. In this study, we acquired diffusion tensor imaging datasets from 30 FE-SCZ patients and 34 age- and gender-matched healthy controls. Taking a distinct gray matter region as a node, inter-regional connectivity as edge and the corresponding streamline counts as edge weight, we constructed whole-brain anatomical networks for both groups, calculated their topological parameters using graph theory, and compared their between-group differences using nonparametric permutation tests. In addition, network-based statistic method was utilized to identify inter-regional connections which were impaired in the FE-SCZ patients. We detected only significantly decreased inter-regional connections in the FE-SCZ patients compared to the controls. These connections were primarily located in the frontal, parietal, occipital, and subcortical regions. Although small-worldness was conserved in the FE-SCZ patients, we found that the network strength and global efficiency as well as the degree were significantly decreased, and shortest path length was significantly increased in the FE-SCZ patients compared to the controls. Most of the regions that showed significantly decreased nodal parameters belonged to the top-down control, sensorimotor, basal ganglia, and limbic-visual system systems. Correlation analysis indicated that the nodal efficiency in the sensorimotor system was negatively correlated with the severity of psychosis symptoms in the FE-SCZ patients. Our results suggest that the network organization is changed in the early stages of the SCZ disease process. Our findings provide useful information for further understanding the brain white matter dysconnectivity of schizophrenia. Springer-Verlag Berlin Heidelberg, 2014 Diffusion tensor imaging (DTI) nationallicence Tractography nationallicence Networks nationallicence Robustness nationallicence Dysconnectivity nationallicence Zhang Ruibin Brain Imaging Center, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for the Study of Applied Psychology, School of Psychology, South China Normal University, 510631, Guangzhou, People's Republic of China aut Wei Qinling Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, 510631, Guangzhou, People's Republic of China aut Kang Zhuang Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, 510631, Guangzhou, People's Republic of China aut Zalesky Andrew Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, VIC, Australia aut Li Meng Brain Imaging Center, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for the Study of Applied Psychology, School of Psychology, South China Normal University, 510631, Guangzhou, People's Republic of China aut Xu Yong Brain Imaging Center, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for the Study of Applied Psychology, School of Psychology, South China Normal University, 510631, Guangzhou, People's Republic of China aut Li Leijun Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, 510631, Guangzhou, People's Republic of China aut Wang Junjing Brain Imaging Center, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for the Study of Applied Psychology, School of Psychology, South China Normal University, 510631, Guangzhou, People's Republic of China aut Zheng Liangrong Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, 510631, Guangzhou, People's Republic of China aut Wang Bin Brain Imaging Center, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for the Study of Applied Psychology, School of Psychology, South China Normal University, 510631, Guangzhou, People's Republic of China aut Zhao Jingping Mental Health Institute, The Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, People's Republic of China aut Zhang Jinbei Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, 510631, Guangzhou, People's Republic of China aut Huang Ruiwang Brain Imaging Center, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for the Study of Applied Psychology, School of Psychology, South China Normal University, 510631, Guangzhou, People's Republic of China aut Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 1145-1159 1863-2653 220:2<1145 2015 220 429 https://doi.org/10.1007/s00429-014-0706-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0706-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang Ruibin Brain Imaging Center, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for the Study of Applied Psychology, School of Psychology, South China Normal University, 510631, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Wei Qinling Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, 510631, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Kang Zhuang Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, 510631, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Zalesky Andrew Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, VIC, Australia aut NATIONALLICENCE 700 1- Li Meng Brain Imaging Center, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for the Study of Applied Psychology, School of Psychology, South China Normal University, 510631, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Xu Yong Brain Imaging Center, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for the Study of Applied Psychology, School of Psychology, South China Normal University, 510631, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Li Leijun Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, 510631, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Wang Junjing Brain Imaging Center, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for the Study of Applied Psychology, School of Psychology, South China Normal University, 510631, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Zheng Liangrong Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, 510631, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Wang Bin Brain Imaging Center, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for the Study of Applied Psychology, School of Psychology, South China Normal University, 510631, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Zhao Jingping Mental Health Institute, The Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Jinbei Department of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, 510631, Guangzhou, People's Republic of China aut NATIONALLICENCE 700 1- Huang Ruiwang Brain Imaging Center, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for the Study of Applied Psychology, School of Psychology, South China Normal University, 510631, Guangzhou, People's Republic of China aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 1145-1159 1863-2653 220:2<1145 2015 220 429