caa a22 4500 606203273 CHVBK 20210128100957.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00429-013-0696-2 doi (NATIONALLICENCE)springer-10.1007/s00429-013-0696-2 Age-related decrease of functional connectivity additional to gray matter atrophy in a network for movement initiation [Elektronische Daten] [F. Hoffstaedter, C. Grefkes, C. Roski, S. Caspers, K. Zilles, S. Eickhoff] Healthy aging is accompanied by a decrease in cognitive and motor capacities. In a network associated with movement initiation, we investigated age-related changes of functional connectivity (FC) as well as regional atrophy in a sample of 232 healthy subjects (age range 18-85years). To this end, voxel-based morphometry and whole-brain resting-state FC were analyzed for the supplementary motor area (SMA), anterior midcingulate cortex (aMCC) and bilateral striatum (Str). To assess the specificity of age-related effects, bilateral primary sensorimotor cortex (S1/M1) closely associated with motor execution was used as control seeds. All regions showed strong reduction of gray matter volume with age. Corrected for this regional atrophy, the FC analysis revealed an age×seed interaction for each of the bilateral Str nodes against S1/M1 with consistent age-related decrease in FC with bilateral caudate nucleus and anterior putamen. Specific age-dependent FC decline of SMA was found in bilateral central insula and the adjacent frontal operculum. aMCC showed exclusive age-related decoupling from the anterior cingulate motor area. The present study demonstrates network as well as node-specific age-dependent FC decline of the SMA and aMCC to highly integrative cortical areas involved in cognitive motor control. FC decrease in addition to gray matter atrophy within the Str may provide a substrate for the declining motor control in elderly. Finally, age-related FC changes in both the network for movement initiation as well as the network for motor execution are not explained by regional atrophy in the healthy aging brain. Springer-Verlag Berlin Heidelberg, 2014 Gray matter atrophy nationallicence Voxel-based morphometry nationallicence Functional connectivity nationallicence Resting-state fMRI nationallicence Aging nationallicence Movement initiation nationallicence Hoffstaedter F. Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut Grefkes C. Max-Planck-Institute for Neurological Research, Neuromodulation and Neurorehabilitation, Cologne, Germany aut Roski C. Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut Caspers S. Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut Zilles K. Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut Eickhoff S. Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 999-1012 1863-2653 220:2<999 2015 220 429 https://doi.org/10.1007/s00429-013-0696-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0696-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hoffstaedter F. Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut NATIONALLICENCE 700 1- Grefkes C. Max-Planck-Institute for Neurological Research, Neuromodulation and Neurorehabilitation, Cologne, Germany aut NATIONALLICENCE 700 1- Roski C. Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut NATIONALLICENCE 700 1- Caspers S. Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut NATIONALLICENCE 700 1- Zilles K. Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut NATIONALLICENCE 700 1- Eickhoff S. Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425, Jülich, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 999-1012 1863-2653 220:2<999 2015 220 429