caa a22 4500 606203311 CHVBK 20210128100957.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00429-013-0679-3 doi (NATIONALLICENCE)springer-10.1007/s00429-013-0679-3 Is silence golden? Effects of auditory stimuli and their absence on adult hippocampal neurogenesis [Elektronische Daten] [Imke Kirste, Zeina Nicola, Golo Kronenberg, Tara Walker, Robert Liu, Gerd Kempermann] We have previously hypothesized that the reason why physical activity increases precursor cell proliferation in adult neurogenesis is that movement serves as non-specific signal to evoke the alertness required to meet cognitive demands. Thereby a pool of immature neurons is generated that are potentially recruitable by subsequent cognitive stimuli. Along these lines, we here tested whether auditory stimuli might exert a similar non-specific effect on adult neurogenesis in mice. We used the standard noise level in the animal facility as baseline and compared this condition to white noise, pup calls, and silence. In addition, as patterned auditory stimulus without ethological relevance to mice we used piano music by Mozart (KV 448). All stimuli were transposed to the frequency range of C57BL/6 and hearing was objectified with acoustic evoked potentials. We found that except for white noise all stimuli, including silence, increased precursor cell proliferation (assessed 24h after labeling with bromodeoxyuridine, BrdU). This could be explained by significant increases in BrdU-labeled Sox2-positive cells (type-1/2a). But after 7days, only silence remained associated with increased numbers of BrdU-labeled cells. Compared to controls at this stage, exposure to silence had generated significantly increased numbers of BrdU/NeuN-labeled neurons. Our results indicate that the unnatural absence of auditory input as well as spectrotemporally rich albeit ethological irrelevant stimuli activate precursor cells—in the case of silence also leading to greater numbers of newborn immature neurons—whereas ambient and unstructured background auditory stimuli do not. The Author(s), 2013 Plasticity nationallicence Stem cells nationallicence Hippocampus nationallicence Mouse nationallicence Learning nationallicence Kirste Imke CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden, Germany aut Nicola Zeina CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden, Germany aut Kronenberg Golo Klinik und Poliklinik für Psychiatrie und Psychotherapie, Charité- Universitätsmedizin Berlin, Charité Campus Mitte, 10117, Berlin, Germany aut Walker Tara CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden, Germany aut Liu Robert Department of Biology, Emory University, Atlanta, GA, USA aut Kempermann Gerd CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 1221-1228 1863-2653 220:2<1221 2015 220 429 https://doi.org/10.1007/s00429-013-0679-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 brief-communication jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0679-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kirste Imke CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Nicola Zeina CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Kronenberg Golo Klinik und Poliklinik für Psychiatrie und Psychotherapie, Charité- Universitätsmedizin Berlin, Charité Campus Mitte, 10117, Berlin, Germany aut NATIONALLICENCE 700 1- Walker Tara CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Liu Robert Department of Biology, Emory University, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Kempermann Gerd CRTD, DFG Research Center for Regenerative Therapies Dresden, Fetscherstraße 105, 01307, Dresden, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 1221-1228 1863-2653 220:2<1221 2015 220 429