caa a22 4500 60620332X CHVBK 20210128100957.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00429-013-0681-9 doi (NATIONALLICENCE)springer-10.1007/s00429-013-0681-9 Differentially disrupted functional connectivity of the subregions of the inferior parietal lobule in Alzheimer's disease [Elektronische Daten] [Zhiqun Wang, Mingrui Xia, Zhengjia Dai, Xia Liang, Haiqing Song, Yong He, Kuncheng Li] Recent research on Alzheimer's disease (AD) has shown that the altered structure and function of the inferior parietal lobule (IPL) provides a promising indicator of AD. However, little is known about the functional connectivity of the IPL subregions in AD subjects. In this study, we collected resting-state functional magnetic resonance imaging data from 32 AD patients and 38 healthy controls. We defined seven subregions of the IPL according to probabilistic cytoarchitectonic atlases and mapped the whole-brain resting-state functional connectivity for each subregion. Using hierarchical clustering analysis, we identified three distinct functional connectivity patterns of the IPL subregions: the anterior IPL connected with the sensorimotor network (SMN) and salience network (SN); the central IPL had connectivity with the executive-control network (ECN); and the posterior IPL exhibited connections with the default-mode network (DMN). Compared with the controls, the AD patients demonstrated distinct disruptive patterns of the IPL subregional connectivity with these different networks (SMN, SN, ECN and DMN), which suggests the impairment of the functional integration in the IPL. Notably, we also observed that the IPL subregions showed increased connectivity with the posterior part of the DMN in AD patients, which potentially indicates a compensatory mechanism. Finally, these abnormal IPL functional connectivity changes were closely associated with cognitive performance. Collectively, we show that the subregions of the IPL present distinct functional connectivity patterns with various functional networks that are differentially impaired in AD patients. Our results also suggest that functional disconnection and compensation in the IPL may coexist in AD. Springer-Verlag Berlin Heidelberg, 2013 Supramarginal gyrus nationallicence Angular gyrus nationallicence Network nationallicence fMRI nationallicence Alzheimer disease nationallicence Wang Zhiqun Department of Radiology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China aut Xia Mingrui State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, 100875, Beijing, China aut Dai Zhengjia State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, 100875, Beijing, China aut Liang Xia State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, 100875, Beijing, China aut Song Haiqing Department of Neurology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China aut He Yong State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, 100875, Beijing, China aut Li Kuncheng Department of Radiology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China aut Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 745-762 1863-2653 220:2<745 2015 220 429 https://doi.org/10.1007/s00429-013-0681-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0681-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Zhiqun Department of Radiology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China aut NATIONALLICENCE 700 1- Xia Mingrui State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, 100875, Beijing, China aut NATIONALLICENCE 700 1- Dai Zhengjia State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, 100875, Beijing, China aut NATIONALLICENCE 700 1- Liang Xia State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, 100875, Beijing, China aut NATIONALLICENCE 700 1- Song Haiqing Department of Neurology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China aut NATIONALLICENCE 700 1- He Yong State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, 100875, Beijing, China aut NATIONALLICENCE 700 1- Li Kuncheng Department of Radiology, Xuanwu Hospital of Capital Medical University, 100053, Beijing, China aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 745-762 1863-2653 220:2<745 2015 220 429