caa a22 4500 606203346 CHVBK 20210128100957.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00429-013-0700-x doi (NATIONALLICENCE)springer-10.1007/s00429-013-0700-x Anterior-posterior dissociation of the default mode network in dogs [Elektronische Daten] [Sreenath Kyathanahally, Hao Jia, Oleg Pustovyy, Paul Waggoner, Ronald Beyers, John Schumacher, Jay Barrett, Edward Morrison, Nouha Salibi, Thomas Denney, Vitaly Vodyanoy, Gopikrishna Deshpande] The default mode network (DMN) in humans has been extensively studied using seed-based correlation analysis (SCA) and independent component analysis (ICA). While DMN has been observed in monkeys as well, there are conflicting reports on whether they exist in rodents. Dogs are higher mammals than rodents, but cognitively not as advanced as monkeys and humans. Therefore, they are an interesting species in the evolutionary hierarchy for probing the comparative functions of the DMN across species. In this study, we sought to know whether the DMN, and consequently its functions such as self-referential processing, are exclusive to humans/monkeys or can we also observe the DMN in animals such as dogs. To address this issue, resting state functional MRI data from the brains of lightly sedated dogs and unconstrained and fully awake dogs were acquired, and ICA and SCA were performed for identifying the DMN. Since anesthesia can alter resting state networks, confirming our results in awake dogs was essential. Awake dog imaging was accomplished by training the dogs to keep their head still using reinforcement behavioral adaptation techniques. We found that the anterior (such as anterior cingulate and medial frontal) and posterior regions (such as posterior cingulate) of the DMN were dissociated in both awake and anesthetized dogs. Springer-Verlag Berlin Heidelberg, 2014 Dog nationallicence Resting state nationallicence Awake animal imaging nationallicence Rest animal imaging nationallicence Functional MRI nationallicence Default mode network (DMN) nationallicence Independent component analysis nationallicence Kyathanahally Sreenath AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA aut Jia Hao AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA aut Pustovyy Oleg Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, USA aut Waggoner Paul Canine Detection Research Institute, Auburn University, Auburn, AL, USA aut Beyers Ronald AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA aut Schumacher John Department of Clinical Sciences, Auburn University, Auburn, AL, USA aut Barrett Jay College of Veterinary Medicine, Auburn University, Auburn, AL, USA aut Morrison Edward Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, USA aut Salibi Nouha AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA aut Denney Thomas AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA aut Vodyanoy Vitaly Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, USA aut Deshpande Gopikrishna AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA aut Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 1063-1076 1863-2653 220:2<1063 2015 220 429 https://doi.org/10.1007/s00429-013-0700-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0700-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kyathanahally Sreenath AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA aut NATIONALLICENCE 700 1- Jia Hao AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA aut NATIONALLICENCE 700 1- Pustovyy Oleg Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, USA aut NATIONALLICENCE 700 1- Waggoner Paul Canine Detection Research Institute, Auburn University, Auburn, AL, USA aut NATIONALLICENCE 700 1- Beyers Ronald AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA aut NATIONALLICENCE 700 1- Schumacher John Department of Clinical Sciences, Auburn University, Auburn, AL, USA aut NATIONALLICENCE 700 1- Barrett Jay College of Veterinary Medicine, Auburn University, Auburn, AL, USA aut NATIONALLICENCE 700 1- Morrison Edward Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, USA aut NATIONALLICENCE 700 1- Salibi Nouha AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA aut NATIONALLICENCE 700 1- Denney Thomas AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA aut NATIONALLICENCE 700 1- Vodyanoy Vitaly Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, USA aut NATIONALLICENCE 700 1- Deshpande Gopikrishna AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 1063-1076 1863-2653 220:2<1063 2015 220 429