caa a22 4500 606203397 CHVBK 20210128100957.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00429-013-0698-0 doi (NATIONALLICENCE)springer-10.1007/s00429-013-0698-0 Definition and characterization of an extended social-affective default network [Elektronische Daten] [Maren Amft, Danilo Bzdok, Angela Laird, Peter Fox, Leonhard Schilbach, Simon Eickhoff] Recent evidence suggests considerable overlap between the default mode network (DMN) and regions involved in social, affective and introspective processes. We considered these overlapping regions as the social-affective part of the DMN. In this study, we established a robust mapping of the underlying brain network formed by these regions and those strongly connected to them (the extended social-affective default network). We first seeded meta-analytic connectivity modeling and resting-state analyses in the meta-analytically defined DMN regions that showed statistical overlap with regions associated with social and affective processing. Consensus connectivity of each seed was subsequently delineated by a conjunction across both connectivity analyses. We then functionally characterized the ensuing regions and performed several cluster analyses. Among the identified regions, the amygdala/hippocampus formed a cluster associated with emotional processes and memory functions. The ventral striatum, anterior cingulum, subgenual cingulum and ventromedial prefrontal cortex formed a heterogeneous subgroup associated with motivation, reward and cognitive modulation of affect. Posterior cingulum/precuneus and dorsomedial prefrontal cortex were associated with mentalizing, self-reference and autobiographic information. The cluster formed by the temporo-parietal junction and anterior middle temporal sulcus/gyrus was associated with language and social cognition. Taken together, the current work highlights a robustly interconnected network that may be central to introspective, socio-affective, that is, self- and other-related mental processes. Springer-Verlag Berlin Heidelberg, 2014 Default mode network nationallicence Meta-analytic connectivity modeling nationallicence Resting-state functional connectivity nationallicence Social cognition nationallicence Emotion nationallicence Amft Maren Institute of Clinical Neuroscience and Medical Psychology, HHU Düsseldorf, Düsseldorf, Germany aut Bzdok Danilo Institute of Clinical Neuroscience and Medical Psychology, HHU Düsseldorf, Düsseldorf, Germany aut Laird Angela Department of Physics, Florida International University, Miami, USA aut Fox Peter Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, USA aut Schilbach Leonhard Department of Psychiatry, University of Cologne, Cologne, Germany aut Eickhoff Simon Institute of Clinical Neuroscience and Medical Psychology, HHU Düsseldorf, Düsseldorf, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 1031-1049 1863-2653 220:2<1031 2015 220 429 https://doi.org/10.1007/s00429-013-0698-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0698-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Amft Maren Institute of Clinical Neuroscience and Medical Psychology, HHU Düsseldorf, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Bzdok Danilo Institute of Clinical Neuroscience and Medical Psychology, HHU Düsseldorf, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Laird Angela Department of Physics, Florida International University, Miami, USA aut NATIONALLICENCE 700 1- Fox Peter Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, USA aut NATIONALLICENCE 700 1- Schilbach Leonhard Department of Psychiatry, University of Cologne, Cologne, Germany aut NATIONALLICENCE 700 1- Eickhoff Simon Institute of Clinical Neuroscience and Medical Psychology, HHU Düsseldorf, Düsseldorf, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 1031-1049 1863-2653 220:2<1031 2015 220 429