caa a22 4500 606203400 CHVBK 20210128100957.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00429-013-0699-z doi (NATIONALLICENCE)springer-10.1007/s00429-013-0699-z Dorsal hippocampal brain receptor complexes linked to the protein synthesis-dependent late phase (LTP) in the rat [Elektronische Daten] [Lin Li, Han Wang, Maryam Ghafari, Gunyong An, Volker Korz, Gert Lubec] In order to link major brain receptor complex levels to in vivo electrically induced LTP, a bipolar stimulation electrode was chronically implanted into the perforant path, while two monopolar recording electrodes were implanted into the dentate gyrus of the dorsal hippocampus. The recording electrode was measuring extracellular excitatory postsynaptic potentials, while the other one measured population spikes. Immunoblotting of native receptor proteins was carried out in the DH based upon blue-native gel electrophoresis and immunoprecipitation followed by mass spectrometrical identification of the NR1-GluA1-GluA2 complex was used to provide evidence for complex formation. The induction of LTP in DH was proven and NMDA receptor complex levels containing NR1, GluA1, GluA2 and GluA3 were modulated by LTP induction. The LTP-associated changes of receptor complex levels may indicate concerted action, interaction and represent a pattern of major brain receptor complexes in the DH following electrical induction of LTP in the rat. Springer-Verlag Berlin Heidelberg, 2014 LTP nationallicence Hippocampus nationallicence Brain receptor complexes nationallicence Li Lin Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria aut Wang Han Institute of Biology, Otto von Guericke University Magdeburg, 39120, Magdeburg, Germany aut Ghafari Maryam Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria aut An Gunyong Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria aut Korz Volker Institute of Biology, Otto von Guericke University Magdeburg, 39120, Magdeburg, Germany aut Lubec Gert Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria aut Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 1051-1062 1863-2653 220:2<1051 2015 220 429 https://doi.org/10.1007/s00429-013-0699-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0699-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Lin Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Wang Han Institute of Biology, Otto von Guericke University Magdeburg, 39120, Magdeburg, Germany aut NATIONALLICENCE 700 1- Ghafari Maryam Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- An Gunyong Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Korz Volker Institute of Biology, Otto von Guericke University Magdeburg, 39120, Magdeburg, Germany aut NATIONALLICENCE 700 1- Lubec Gert Department of Pediatrics, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 1051-1062 1863-2653 220:2<1051 2015 220 429