caa a22 4500 606203435 CHVBK 20210128100957.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00429-014-0713-0 doi (NATIONALLICENCE)springer-10.1007/s00429-014-0713-0 Differential impact of chronic stress along the hippocampal dorsal-ventral axis [Elektronische Daten] [V. Pinto, J. Costa, P. Morgado, C. Mota, A. Miranda, F. Bravo, T. Oliveira, J. Cerqueira, N. Sousa] Stress impacts differently in distinct brain regions. However, so far few studies have focused on the differential responses triggered by stressful stimuli on the intrinsic functional heterogeneity of the hippocampal axis. In this study, we assessed the functional and structural alterations caused by exposure to a chronic unpredictable stress (CUS) paradigm on the dorsal-ventral axis of the hippocampus. The morphological analysis demonstrated that CUS had opposite outcomes in the structure of the dorsal (DH) and ventral hippocampus (VH): whereas in the DH, stress triggered a volumetric reduction as a result of atrophy of CA3 and CA1 apical dendrites, in the VH there was an increase in hippocampal volume concurrent with the increase of CA3 apical dendrites. In parallel, electrophysiological data revealed that stress led to a decrease in VH LTD. In summary, the present work showed that stress impacts differently on the structure and function of the DH and VH which contributes to better understand the overall spectrum of the central effects of stress. Springer-Verlag Berlin Heidelberg, 2014 Chronic stress nationallicence Hippocampal axis nationallicence LTP nationallicence LTD nationallicence Morphology nationallicence Pinto V. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut Costa J. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut Morgado P. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut Mota C. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut Miranda A. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut Bravo F. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut Oliveira T. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut Cerqueira J. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut Sousa N. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 1205-1212 1863-2653 220:2<1205 2015 220 429 https://doi.org/10.1007/s00429-014-0713-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 brief-communication jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0713-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pinto V. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut NATIONALLICENCE 700 1- Costa J. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut NATIONALLICENCE 700 1- Morgado P. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut NATIONALLICENCE 700 1- Mota C. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut NATIONALLICENCE 700 1- Miranda A. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut NATIONALLICENCE 700 1- Bravo F. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut NATIONALLICENCE 700 1- Oliveira T. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut NATIONALLICENCE 700 1- Cerqueira J. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut NATIONALLICENCE 700 1- Sousa N. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 1205-1212 1863-2653 220:2<1205 2015 220 429