caa a22 4500 60620346X CHVBK 20210128100957.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00429-013-0695-3 doi (NATIONALLICENCE)springer-10.1007/s00429-013-0695-3 The neurobiology of speech perception decline in aging [Elektronische Daten] [Mylène Bilodeau-Mercure, Catherine Lortie, Marc Sato, Matthieu Guitton, Pascale Tremblay] Speech perception difficulties are common among elderlies; yet the underlying neural mechanisms are still poorly understood. New empirical evidence suggesting that brain senescence may be an important contributor to these difficulties has challenged the traditional view that peripheral hearing loss was the main factor in the etiology of these difficulties. Here, we investigated the relationship between structural and functional brain senescence and speech perception skills in aging. Following audiometric evaluations, participants underwent MRI while performing a speech perception task at different intelligibility levels. As expected, with age speech perception declined, even after controlling for hearing sensitivity using an audiological measure (pure tone averages), and a bioacoustical measure (DPOAEs recordings). Our results reveal that the core speech network, centered on the supratemporal cortex and ventral motor areas bilaterally, decreased in spatial extent in older adults. Importantly, our results also show that speech skills in aging are affected by changes in cortical thickness and in brain functioning. Age-independent intelligibility effects were found in several motor and premotor areas, including the left ventral premotor cortex and the right supplementary motor area (SMA). Age-dependent intelligibility effects were also found, mainly in sensorimotor cortical areas, and in the left dorsal anterior insula. In this region, changes in BOLD signal modulated the relationship between age and speech perception skills suggesting a role for this region in maintaining speech perception in older ages. These results provide important new insights into the neurobiology of speech perception in aging. Springer-Verlag Berlin Heidelberg, 2014 Speech intelligibility nationallicence Language nationallicence Functional magnetic resonance imaging nationallicence Brain senescence nationallicence Insula nationallicence Premotor cortex nationallicence Bilodeau-Mercure Mylène Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, G1J 2G3, Quebec City, QC, Canada aut Lortie Catherine Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, G1J 2G3, Quebec City, QC, Canada aut Sato Marc GIPSA-lab, CNRS, Université de Grenoble, Saint-Martin-d'Hères, France aut Guitton Matthieu Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, G1J 2G3, Quebec City, QC, Canada aut Tremblay Pascale Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, G1J 2G3, Quebec City, QC, Canada aut Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 979-997 1863-2653 220:2<979 2015 220 429 https://doi.org/10.1007/s00429-013-0695-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0695-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bilodeau-Mercure Mylène Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, G1J 2G3, Quebec City, QC, Canada aut NATIONALLICENCE 700 1- Lortie Catherine Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, G1J 2G3, Quebec City, QC, Canada aut NATIONALLICENCE 700 1- Sato Marc GIPSA-lab, CNRS, Université de Grenoble, Saint-Martin-d'Hères, France aut NATIONALLICENCE 700 1- Guitton Matthieu Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, G1J 2G3, Quebec City, QC, Canada aut NATIONALLICENCE 700 1- Tremblay Pascale Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec, G1J 2G3, Quebec City, QC, Canada aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 979-997 1863-2653 220:2<979 2015 220 429