caa a22 4500 606203486 CHVBK 20210128100958.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00429-014-0715-y doi (NATIONALLICENCE)springer-10.1007/s00429-014-0715-y Influence of ontogenetic age on the role of dentate granule neurons [Elektronische Daten] [Sophie Tronel, Valérie Lemaire, Vanessa Charrier, Marie-Françoise Montaron, Djoher Abrous] New neurons are continuously produced in the adult dentate gyrus of the hippocampus, a key structure in learning and memory. It has been shown that adult neurogenesis is crucial for normal memory processing. However, it is not known whether neurons born during the developmental period and during adulthood support the same functions. Here, we demonstrate that neurons born in neonates (first postnatal week) are activated in different memory processes when they are mature compared to neurons born in adults. By imaging the activation of these two different neuron generations in the same rat and using the IEG Zif268 and Fos, we show that these neurons are involved in discriminating dissimilar contexts and spatial problem solving, respectively. These findings demonstrate that the ontogenetic stage during which neurons are generated is crucial for their function within the memory network. Springer-Verlag Berlin Heidelberg, 2014 Adult neurogenesis nationallicence Hippocampus nationallicence Spatial memory nationallicence Developmental neurogenesis nationallicence Memory nationallicence Tronel Sophie Inserm U862, 33077, Bordeaux, France aut Lemaire Valérie Inserm U862, 33077, Bordeaux, France aut Charrier Vanessa Inserm U862, 33077, Bordeaux, France aut Montaron Marie-Françoise Inserm U862, 33077, Bordeaux, France aut Abrous Djoher Inserm U862, 33077, Bordeaux, France aut Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 645-661 1863-2653 220:2<645 2015 220 429 https://doi.org/10.1007/s00429-014-0715-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-014-0715-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tronel Sophie Inserm U862, 33077, Bordeaux, France aut NATIONALLICENCE 700 1- Lemaire Valérie Inserm U862, 33077, Bordeaux, France aut NATIONALLICENCE 700 1- Charrier Vanessa Inserm U862, 33077, Bordeaux, France aut NATIONALLICENCE 700 1- Montaron Marie-Françoise Inserm U862, 33077, Bordeaux, France aut NATIONALLICENCE 700 1- Abrous Djoher Inserm U862, 33077, Bordeaux, France aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 645-661 1863-2653 220:2<645 2015 220 429