caa a22 4500 606203540 CHVBK 20210128100958.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00429-013-0688-2 doi (NATIONALLICENCE)springer-10.1007/s00429-013-0688-2 Early life stress and sex-specific sensitivity of the catecholaminergic systems in prefrontal and limbic regions of Octodon degus [Elektronische Daten] [Jan Kunzler, Katharina Braun, Joerg Bock] Previous work in the precocious rodent Octodon degus has shown that exposure to early life stress (ELS) (induced by repeated parental separation) results in changes of excitatory, inhibitory and modulatory transmitter systems in prefrontal and limbic regions of the male brain. The aim of this study was to test the hypothesis that catecholaminergic fibers and dopamine transporters (DAT) are differentially vulnerable towards ELS-induced neuronal changes in male and female brains. The brains of adult male and female animals exposed to repeated early life stress (1h/day separation from the family from P1 to P21) and control animals were compared and the densities of tyrosine hydroxylase (TH)-immunoreactive structures were quantified in prefrontal cortical regions. In the nucleus accumbens (NAc) and striatum, DAT-immunoreactivity as well as TH immunoreactivity was measured. Layer II of the prelimbic cortex displayed reduced TH-fiber densities in ELS males compared to control males; this effect was not seen in females. In contrast, layer V/VI of the lateral orbitofrontal cortex displayed elevated fiber densities in ELS males compared to controls; again this difference was not observed in females. The same trend was observed for layer III/IV of the ventral orbitofrontal cortex. No sex-specific effects in response to ELS were observed for DAT, whose density was elevated in the NAc of ELS males and females. These results are in line with our working hypothesis that ELS affects the development of catecholaminergic systems and we show here that ELS-induced differences of TH-immunoreactive fibers were more pronounced in male brains than in female brains. Springer-Verlag Berlin Heidelberg, 2013 Prefrontal cortex nationallicence Limbic system nationallicence Dopamine nationallicence Early life stress nationallicence Sex differences nationallicence Kunzler Jan Department of Zoology/Developmental Neurobiology, Institute of Biology, Otto von Guericke University Magdeburg, Magdeburg, Germany aut Braun Katharina Department of Zoology/Developmental Neurobiology, Institute of Biology, Otto von Guericke University Magdeburg, Magdeburg, Germany aut Bock Joerg PG "Epigenetics and Structural Plasticity”, Institute of Biology, Otto von Guericke University Magdeburg, Magdeburg, Germany aut Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 861-868 1863-2653 220:2<861 2015 220 429 https://doi.org/10.1007/s00429-013-0688-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 brief-communication jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00429-013-0688-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kunzler Jan Department of Zoology/Developmental Neurobiology, Institute of Biology, Otto von Guericke University Magdeburg, Magdeburg, Germany aut NATIONALLICENCE 700 1- Braun Katharina Department of Zoology/Developmental Neurobiology, Institute of Biology, Otto von Guericke University Magdeburg, Magdeburg, Germany aut NATIONALLICENCE 700 1- Bock Joerg PG "Epigenetics and Structural Plasticity”, Institute of Biology, Otto von Guericke University Magdeburg, Magdeburg, Germany aut NATIONALLICENCE 773 0- Brain Structure and Function Springer Berlin Heidelberg 220/2(2015-03-01), 861-868 1863-2653 220:2<861 2015 220 429