caa a22 4500 60620363X CHVBK 20210128100958.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10484-014-9267-4 doi (NATIONALLICENCE)springer-10.1007/s10484-014-9267-4 Effect of Neurofeedback Training on Depression and Fatigue in Patients with Multiple Sclerosis [Elektronische Daten] [Azadeh Choobforoushzadeh, Hamid Neshat-Doost, Hossien Molavi, Mohammad Abedi] Depression and fatigue are common symptoms of multiple sclerosis (MS) and are the primary determinants of impaired quality of life in this demyelinating neurological disease. Untreated depression is associated with suicidal ideation, impaired cognitive function and poor adherence to immunomodulatory treatment. For these reasons, systematic screening and management of depressive symptoms and fatigue is recommended for all patients with MS. The objective of this study was to evaluate the effectiveness of neurofeedback in treating depression and fatigue in persons with MS. We conducted a randomized trial with 24 MS patients with primary fatigue and depression. Participants were randomized into two groups: neurofeedback training group (16 sessions of NFB) or treatment as usual. Participants were evaluated at 3 time points (baseline, end of the treatment, and 2-month follow-up) using the Fatigue Severity Scale and Depression subscale of the Hospital Anxiety and Depression Scale as outcome measures. A repeated measures analysis of variance was used to examine differences between the groups. NFB significantly reduced symptoms of depression and fatigue in patients with MS patients, compared to treatment as usual (p<.05), and these effects were maintained the 2-month follow-up (p<.05). Springer Science+Business Media New York, 2014 Multiple sclerosis nationallicence Fatigue nationallicence Depression nationallicence Neurofeedback nationallicence Fatigue Severity Scale nationallicence Hospital Anxiety and Depression Scale nationallicence Choobforoushzadeh Azadeh Department of Psychology, University of Isfahan, Isfahan, Iran aut Neshat-Doost Hamid Department of Psychology, University of Isfahan, Isfahan, Iran aut Molavi Hossien Department of Psychology, University of Isfahan, Isfahan, Iran aut Abedi Mohammad Department of Counseling, University of Isfahan, Isfahan, Iran aut Applied Psychophysiology and Biofeedback Springer US; http://www.springer-ny.com 40/1(2015-03-01), 1-8 1090-0586 40:1<1 2015 40 10484 https://doi.org/10.1007/s10484-014-9267-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10484-014-9267-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Choobforoushzadeh Azadeh Department of Psychology, University of Isfahan, Isfahan, Iran aut NATIONALLICENCE 700 1- Neshat-Doost Hamid Department of Psychology, University of Isfahan, Isfahan, Iran aut NATIONALLICENCE 700 1- Molavi Hossien Department of Psychology, University of Isfahan, Isfahan, Iran aut NATIONALLICENCE 700 1- Abedi Mohammad Department of Counseling, University of Isfahan, Isfahan, Iran aut NATIONALLICENCE 773 0- Applied Psychophysiology and Biofeedback Springer US; http://www.springer-ny.com 40/1(2015-03-01), 1-8 1090-0586 40:1<1 2015 40 10484