caa a22 4500 606203907 CHVBK 20210128100959.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10484-015-9301-1 doi (NATIONALLICENCE)springer-10.1007/s10484-015-9301-1 Serum Leptin and Cortisol, Related to Acutely Perceived Academic Examination Stress and Performance in Female University Students [Elektronische Daten] [Darakhshan Haleem, Qurrat-ul-Aen Inam, Saida Haider, Tahira Perveen, Muhammad Haleem] Leptin, identified as an antiobesity hormone, also has important role in responses to stress and processing of memory. This study was designed to determine effects of academic examination stress-induced changes in serum leptin and its impact on academic performance. Eighty five healthy female students (age 19-21years; BMI 21.9±1.6) were recruited for the study. Serum leptin and cortisol were monitored at base line (beginning of academic session) and on the day of examination; using a standardized ELISA kit. Acute perception of academic examination stress was determined with the help of a questionnaire derived from Hamilton Anxiety Scale and self report of stress perception. Academic performance was evaluated by the percentage of marks obtained in the examination. Serum cortisol levels were positively correlated (p<0.01) with the subjective perception of examination stress but not with academic performance. There was an inverted U-shape relationship between level of stress and academic performance. Leptin increased in all stress groups and correlated (p<0.01) positively with academic performance. There was an inverted U-shape relationship between level of stress and circulating leptin. The findings suggest the peptide hormone, leptin, is a biomarker of stress perception and a mediator of facilitating effects of stress on cognition. Springer Science+Business Media New York, 2015 Stress nationallicence Academic performance nationallicence Cortisol nationallicence Leptin nationallicence Memory nationallicence Depression/anxiety nationallicence Haleem Darakhshan Neuroscience Research Laboratory, Dr Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Karachi, Pakistan aut Inam Qurrat-ul-Aen Neurochemistry and Biochemical Neuropharmacology Research Laboratory, Department of Biochemistry, University of Karachi, Karachi, Pakistan aut Haider Saida Neurochemistry and Biochemical Neuropharmacology Research Laboratory, Department of Biochemistry, University of Karachi, Karachi, Pakistan aut Perveen Tahira Neurochemistry and Biochemical Neuropharmacology Research Laboratory, Department of Biochemistry, University of Karachi, Karachi, Pakistan aut Haleem Muhammad Department of Biomedical Engineering, Sir Syed University of Engineering and Technology, Karachi, Pakistan aut Applied Psychophysiology and Biofeedback Springer US; http://www.springer-ny.com 40/4(2015-12-01), 305-312 1090-0586 40:4<305 2015 40 10484 https://doi.org/10.1007/s10484-015-9301-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10484-015-9301-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Haleem Darakhshan Neuroscience Research Laboratory, Dr Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Karachi, Pakistan aut NATIONALLICENCE 700 1- Inam Qurrat-ul-Aen Neurochemistry and Biochemical Neuropharmacology Research Laboratory, Department of Biochemistry, University of Karachi, Karachi, Pakistan aut NATIONALLICENCE 700 1- Haider Saida Neurochemistry and Biochemical Neuropharmacology Research Laboratory, Department of Biochemistry, University of Karachi, Karachi, Pakistan aut NATIONALLICENCE 700 1- Perveen Tahira Neurochemistry and Biochemical Neuropharmacology Research Laboratory, Department of Biochemistry, University of Karachi, Karachi, Pakistan aut NATIONALLICENCE 700 1- Haleem Muhammad Department of Biomedical Engineering, Sir Syed University of Engineering and Technology, Karachi, Pakistan aut NATIONALLICENCE 773 0- Applied Psychophysiology and Biofeedback Springer US; http://www.springer-ny.com 40/4(2015-12-01), 305-312 1090-0586 40:4<305 2015 40 10484