caa a22 4500 606204210 CHVBK 20210128101001.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10388-013-0408-2 doi (NATIONALLICENCE)springer-10.1007/s10388-013-0408-2 Diffuse large B-cell lymphoma of the thyroid which caused esophageal fistula [Elektronische Daten] [Tomoyasu Tachibana, Yorihisa Orita, Masayoshi Fujisawa, Yasushi Hiramatsu, Yuya Ogawara, Yuko Matsuyama, Iku Abe, Kaori Uchino, Hirofumi Morishita, Tetsuji Nobuhisa, Koichi Uesaka, Kazunori Nishizaki] We describe a rare case of thyroidal Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly (EBV+DLBCLe) in which diagnosis was difficult and spontaneous esophageal fistula developed. A 79-year-old woman presented with acute swelling of the anterior neck with tenderness, general fatigue, and continual fever. Malignant lymphoma of the thyroid was suspected. Histologically, the thyroid lesion showed extensive necrosis, including a few Ziehl-Neelsen-positive substances. No evidence of tuberculosis was detected by any other examinations. While performing examinations, left recurrent nerve palsy and a tumorous lesion in the pharynx appeared. Computed tomography and gastrointestinal fiberscopy revealed esophageal fistula. Biopsy specimens from the pharyngeal lesion showed diffuse proliferation of large atypical lymphoid cells that were strongly positive for CD20 and EBV early RNAs. The final diagnosis was thyroidal EBV+DLBCLe with infiltration of surrounding organs. The esophageal fistula had healed 6months after beginning treatment of EBV+DLBCLe. The Japan Esophageal Society and Springer Japan, 2013 Thyroid nationallicence Diffuse large B-cell lymphoma nationallicence Esophageal fistula nationallicence Tachibana Tomoyasu Department of Otolaryngology, Himeji Red Cross Hospital, Himeji, Japan aut Orita Yorihisa Department of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan aut Fujisawa Masayoshi Department of Pathology, Himeji Red Cross Hospital, Himeji, Japan aut Hiramatsu Yasushi Department of Internal Medicine, Himeji Red Cross Hospital, Himeji, Japan aut Ogawara Yuya Department of Otolaryngology, Himeji Red Cross Hospital, Himeji, Japan aut Matsuyama Yuko Department of Otolaryngology, Himeji Red Cross Hospital, Himeji, Japan aut Abe Iku Department of Otolaryngology, Himeji Red Cross Hospital, Himeji, Japan aut Uchino Kaori Department of Pathology, Himeji Red Cross Hospital, Himeji, Japan aut Morishita Hirofumi Department of Internal Medicine, Himeji Red Cross Hospital, Himeji, Japan aut Nobuhisa Tetsuji Department of Surgery, Himeji Red Cross Hospital, Himeji, Japan aut Uesaka Koichi Department of Internal Medicine, Himeji Red Cross Hospital, Himeji, Japan aut Nishizaki Kazunori Department of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan aut Esophagus Springer Japan 12/1(2015-01-01), 77-81 1612-9059 12:1<77 2015 12 10388 https://doi.org/10.1007/s10388-013-0408-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10388-013-0408-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tachibana Tomoyasu Department of Otolaryngology, Himeji Red Cross Hospital, Himeji, Japan aut NATIONALLICENCE 700 1- Orita Yorihisa Department of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan aut NATIONALLICENCE 700 1- Fujisawa Masayoshi Department of Pathology, Himeji Red Cross Hospital, Himeji, Japan aut NATIONALLICENCE 700 1- Hiramatsu Yasushi Department of Internal Medicine, Himeji Red Cross Hospital, Himeji, Japan aut NATIONALLICENCE 700 1- Ogawara Yuya Department of Otolaryngology, Himeji Red Cross Hospital, Himeji, Japan aut NATIONALLICENCE 700 1- Matsuyama Yuko Department of Otolaryngology, Himeji Red Cross Hospital, Himeji, Japan aut NATIONALLICENCE 700 1- Abe Iku Department of Otolaryngology, Himeji Red Cross Hospital, Himeji, Japan aut NATIONALLICENCE 700 1- Uchino Kaori Department of Pathology, Himeji Red Cross Hospital, Himeji, Japan aut NATIONALLICENCE 700 1- Morishita Hirofumi Department of Internal Medicine, Himeji Red Cross Hospital, Himeji, Japan aut NATIONALLICENCE 700 1- Nobuhisa Tetsuji Department of Surgery, Himeji Red Cross Hospital, Himeji, Japan aut NATIONALLICENCE 700 1- Uesaka Koichi Department of Internal Medicine, Himeji Red Cross Hospital, Himeji, Japan aut NATIONALLICENCE 700 1- Nishizaki Kazunori Department of Otolaryngology, Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan aut NATIONALLICENCE 773 0- Esophagus Springer Japan 12/1(2015-01-01), 77-81 1612-9059 12:1<77 2015 12 10388