caa a22 4500 606204237 CHVBK 20210128101001.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10388-014-0457-1 doi (NATIONALLICENCE)springer-10.1007/s10388-014-0457-1 Morphologic characteristics of esophageal epithelium in a rat model of duodenoesophageal reflux and protective effect of lafutidine [Elektronische Daten] [Natsuya Katada, Jiro Shibuya, Takafumi Ichikawa, Kei Hosoda, Keishi Yamashita, Masahiko Watanabe] Backgrounds: The objectives of this study were to delineate differences in the morphologic characteristics of reflux esophagitis between a rat gastroesophageal reflux (GER) model and a duodenoesophageal reflux (DER) model and to evaluate the effects of H2-receptor antagonists on morphologic characteristics of reflux esophagitis in DER model. Methods: Wistar rats were divided into 3 groups: GER model group (Group G), DER model group (Group D), and control group (Group C). Rats in each group were sacrificed 1 or 12weeks after surgery. Intraesophageal pH was measured, and the excised esophagus was examined macroscopically and histologically. Subgroups of rats in Group D were given famotidine (10mg/kg) or lafutidine (30mg/kg) orally once daily for 1week after surgery. The rats were then sacrificed, and histological findings were compared. Results: Intraesophageal pH was significantly lower in Group G than in Group C. At 12weeks, the epithelium of the lower esophagus in Groups G and D was significantly thicker than that in Group C and showed remarkable hyperplastic changes in Group D. The thickness of the epithelium in Group D+famotidine did not differ significantly from that in Group D. In contrast, the epithelium was significantly thinner in Group D+lafutidine than in Group D. Conclusions: As a rat model of reflux esophagitis, DER causes severer damage to the esophageal epithelium, including hyperplastic changes, than does GER. Famotidine had no apparent effect on esophageal epithelial damage caused by DER, whereas lafutidine was suggested to attenuate such damage. The Japan Esophageal Society and Springer Japan, 2014 Duodenoesophageal reflux nationallicence Rat model nationallicence Lafutidine nationallicence Katada Natsuya Department of Surgery, School of Medicine, Kitasato University, 2-1-1 Asamizodai, Minami-ku, 252-0380, Sagamihara, Kanagawa, Japan aut Shibuya Jiro Department of Surgery, School of Medicine, Kitasato University, 2-1-1 Asamizodai, Minami-ku, 252-0380, Sagamihara, Kanagawa, Japan aut Ichikawa Takafumi Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan aut Hosoda Kei Department of Surgery, School of Medicine, Kitasato University, 2-1-1 Asamizodai, Minami-ku, 252-0380, Sagamihara, Kanagawa, Japan aut Yamashita Keishi Department of Surgery, School of Medicine, Kitasato University, 2-1-1 Asamizodai, Minami-ku, 252-0380, Sagamihara, Kanagawa, Japan aut Watanabe Masahiko Department of Surgery, School of Medicine, Kitasato University, 2-1-1 Asamizodai, Minami-ku, 252-0380, Sagamihara, Kanagawa, Japan aut Esophagus Springer Japan 12/1(2015-01-01), 65-72 1612-9059 12:1<65 2015 12 10388 https://doi.org/10.1007/s10388-014-0457-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10388-014-0457-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Katada Natsuya Department of Surgery, School of Medicine, Kitasato University, 2-1-1 Asamizodai, Minami-ku, 252-0380, Sagamihara, Kanagawa, Japan aut NATIONALLICENCE 700 1- Shibuya Jiro Department of Surgery, School of Medicine, Kitasato University, 2-1-1 Asamizodai, Minami-ku, 252-0380, Sagamihara, Kanagawa, Japan aut NATIONALLICENCE 700 1- Ichikawa Takafumi Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan aut NATIONALLICENCE 700 1- Hosoda Kei Department of Surgery, School of Medicine, Kitasato University, 2-1-1 Asamizodai, Minami-ku, 252-0380, Sagamihara, Kanagawa, Japan aut NATIONALLICENCE 700 1- Yamashita Keishi Department of Surgery, School of Medicine, Kitasato University, 2-1-1 Asamizodai, Minami-ku, 252-0380, Sagamihara, Kanagawa, Japan aut NATIONALLICENCE 700 1- Watanabe Masahiko Department of Surgery, School of Medicine, Kitasato University, 2-1-1 Asamizodai, Minami-ku, 252-0380, Sagamihara, Kanagawa, Japan aut NATIONALLICENCE 773 0- Esophagus Springer Japan 12/1(2015-01-01), 65-72 1612-9059 12:1<65 2015 12 10388