caa a22 4500 606204288 CHVBK 20210128101001.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10388-014-0451-7 doi (NATIONALLICENCE)springer-10.1007/s10388-014-0451-7 Optimal duration of prophylactic antimicrobial administration and risk of postoperative infectious events in thoracic esophagectomy with three-field lymph node dissection: short-course versus prolonged antimicrobial administration [Elektronische Daten] [Takeo Fujita, Hiroyuki Daiko] Background: For prevention of surgical site infections, the current guidelines of Center of Disease Control recommend the maintenance of therapeutic levels of prophylactic antimicrobial agents throughout operations and, at most, for a few hours after incision closure. However, in literature supporting these recommendations, most reports have described combinations of various types of surgical procedures. Consequently, the optimal duration of prophylactic antimicrobial administration in esophagectomy with three-field lymph node dissection has not been fully addressed. Methods: We randomly assigned 257 patients with esophageal cancer who underwent esophagectomy with three-field lymph node dissection into two groups and analyzed the incidences of surgical site and remote infections. Antimicrobial administration began 30min before the skin incision was made and repeated every 3h during the procedure in the short-course administration group, whereas additional administration was postoperatively continued the day after operation in the prolonged administration group. Results: Among the 128/129 patients in the short-course/prolonged administration group, surgical site infections occurred in 26.5%/24.0% (p=0.64), anastomotic leakage in 11.7%/15.5% (p=0.37), and incisional surgical site infections in 14.8%/8.5% patients, respectively (p=0.11). Remote infections occurred in 11.7%/11.6% (p=0.86) patients, respectively, and the median postoperative hospital stay was 14days (p=0.86) in both groups. Conclusions: In esophagectomy with three-field lymph node dissection, short-course antimicrobial administration was sufficient for the prevention of postoperative infectious events. The Japan Esophageal Society and Springer Japan, 2014 Esophageal cancer nationallicence Esophagectomy nationallicence Surgical site infection nationallicence Prophylactic antimicrobial agent nationallicence Fujita Takeo Division of Esophageal Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, 277-0882, Chiba, Japan aut Daiko Hiroyuki Division of Esophageal Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, 277-0882, Chiba, Japan aut Esophagus Springer Japan 12/1(2015-01-01), 38-43 1612-9059 12:1<38 2015 12 10388 https://doi.org/10.1007/s10388-014-0451-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10388-014-0451-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fujita Takeo Division of Esophageal Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, 277-0882, Chiba, Japan aut NATIONALLICENCE 700 1- Daiko Hiroyuki Division of Esophageal Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, 277-0882, Chiba, Japan aut NATIONALLICENCE 773 0- Esophagus Springer Japan 12/1(2015-01-01), 38-43 1612-9059 12:1<38 2015 12 10388