caa a22 4500 606204318 CHVBK 20210128101001.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10388-014-0421-0 doi (NATIONALLICENCE)springer-10.1007/s10388-014-0421-0 G-CSF-producing esophageal cancer with induction of intense bone marrow FDG uptake [Elektronische Daten] [Taro Oshikiri, Takashi Yasuda, Hitoshi Harada, Masato Ohyama, Hiroshi Hasegawa, Tadayuki Ohara, Hiroyoshi Sendo, Takemi Sugimoto, Yasuhiro Fujino, Masahiro Tominaga, Yuichi Takahashi] We report the first case of esophageal squamous cell carcinoma (SCC) producing granulocyte colony-stimulating factor (G-CSF) with induction of high uptake of (18)F-fluorodeoxyglucose (FDG) throughout the bone marrow. A close relationship between tumor status and serum G-CSF concentration was also seen. A 65-year-old man was admitted to our hospital because of esophageal SCC with leukocytosis and pyrexia. His leukocyte count and serum G-CSF concentration were 15900/μl and 140pg/ml, respectively. Positron emission tomography/computed tomography (PET/CT) showed focal intense bone marrow (18)F-FDG uptake. Hypermetabolic activity in the bone marrow was suspected to be an effect of G-CSF. Under the diagnosis of G-CSF-producing esophageal SCC, the patient underwent minimally invasive esophagectomy in the prone position with 2-field lymph node dissection. After removal of the tumor, the leukocyte count and serum G-CSF concentration rapidly normalized. Immunohistochemically, G-CSF expression was found in the cytoplasm of tumor cells. High uptake of (18)F-FDG throughout the bone marrow decreased. The patient left the hospital on postoperative day 10 without any complications. Changes in bone marrow PET/CT findings and serum G-CSF concentration should be helpful in the definitive diagnosis of G-CSF-producing esophageal SCC and serve as an indicator of therapeutic effect. The Japan Esophageal Society and Springer Japan, 2014 Esophageal cancer nationallicence Granulocyte colony-stimulating factor nationallicence Esophagectomy nationallicence (18)F-fluorodeoxyglucose positron emission tomography/computed tomography nationallicence Bone marrow nationallicence Oshikiri Taro Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut Yasuda Takashi Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut Harada Hitoshi Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut Ohyama Masato Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut Hasegawa Hiroshi Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut Ohara Tadayuki Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut Sendo Hiroyoshi Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut Sugimoto Takemi Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut Fujino Yasuhiro Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut Tominaga Masahiro Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut Takahashi Yuichi Department of Pathology, Hyogo Cancer Center, Akashi, Hyogo, Japan aut Esophagus Springer Japan 12/3(2015-07-01), 258-262 1612-9059 12:3<258 2015 12 10388 https://doi.org/10.1007/s10388-014-0421-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10388-014-0421-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oshikiri Taro Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut NATIONALLICENCE 700 1- Yasuda Takashi Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut NATIONALLICENCE 700 1- Harada Hitoshi Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut NATIONALLICENCE 700 1- Ohyama Masato Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut NATIONALLICENCE 700 1- Hasegawa Hiroshi Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut NATIONALLICENCE 700 1- Ohara Tadayuki Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut NATIONALLICENCE 700 1- Sendo Hiroyoshi Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut NATIONALLICENCE 700 1- Sugimoto Takemi Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut NATIONALLICENCE 700 1- Fujino Yasuhiro Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut NATIONALLICENCE 700 1- Tominaga Masahiro Department of Gastroenterological Surgery, Hyogo Cancer Center, 13-70 Kitaoji-cho, 673-8558, Akashi, Hyogo, Japan aut NATIONALLICENCE 700 1- Takahashi Yuichi Department of Pathology, Hyogo Cancer Center, Akashi, Hyogo, Japan aut NATIONALLICENCE 773 0- Esophagus Springer Japan 12/3(2015-07-01), 258-262 1612-9059 12:3<258 2015 12 10388