caa a22 4500 606204342 CHVBK 20210128101002.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10388-014-0480-2 doi (NATIONALLICENCE)springer-10.1007/s10388-014-0480-2 Associations between endoscopic findings and functional assessment via multichannel intraluminal impedance-pH monitoring in patients with non-erosive reflux disease refractory to proton-pump inhibitors [Elektronische Daten] [Yasuhiro Fujiwara, Yukie Kohata, Tetsuya Tanigawa, Hirokazu Yamagami, Masatsugu Shiba, Kazunari Tominaga, Toshio Watanabe, Tetsuo Arakawa] Background and aim: The clinical significance of minimal changes in non-erosive reflux disease (NERD) is controversial. Multichannel intraluminal impedance-pH (MII-pH) monitoring enables classification of NERD. The aim of this study was to evaluate associations between endoscopic findings and functional assessment via MII-pH monitoring in patients with proton-pump inhibitor (PPI)-refractory NERD. Methods: Thirty-four PPI-refractory NERD patients were retrospectively analyzed. On the basis of the MII-pH monitoring results, cases were classified as acid reflux, non-acid reflux, and functional heartburn. Minimal changes such as white turbidity, erythema, loss of fine vascular network pattern at the esophagogastric junction, hyperplasia of vascular network at the middle esophagus, hernia, flap valve grade, and atrophic gastritis were evaluated endoscopically. Results: Among 34 patients, 8 were categorized with acid reflux, 17 with non-acid reflux, and 9 with functional heartburn. There were no differences in the prevalence of minimal changes among the groups, but all cases showing white turbidity of the entire esophageal circumference involved non-acid reflux. The prevalence of hiatal hernia and abnormal flap valve did not differ among the three groups, but the presence of atrophic gastritis was significantly more common in patients with functional heartburn than in those with acid and non-acid reflux. The prevalence of hyperplasia of the vascular network at the middle esophagus was significantly higher in patients with proximal migration than in those without. Conclusion: There are associations between endoscopic findings and functional assessment via MII-pH monitoring. Future studies should pay more attention to the endoscopic findings at the middle esophagus. The Japan Esophageal Society and Springer Japan, 2014 Non-erosive reflux disease nationallicence Minimal change nationallicence Multichannel intraluminal impedance-pH monitoring nationallicence Hyperplasia of vascular network nationallicence Fujiwara Yasuhiro Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, 545-8585, Osaka, Japan aut Kohata Yukie Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, 545-8585, Osaka, Japan aut Tanigawa Tetsuya Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, 545-8585, Osaka, Japan aut Yamagami Hirokazu Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, 545-8585, Osaka, Japan aut Shiba Masatsugu Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, 545-8585, Osaka, Japan aut Tominaga Kazunari Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, 545-8585, Osaka, Japan aut Watanabe Toshio Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, 545-8585, Osaka, Japan aut Arakawa Tetsuo Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, 545-8585, Osaka, Japan aut Esophagus Springer Japan 12/3(2015-07-01), 244-250 1612-9059 12:3<244 2015 12 10388 https://doi.org/10.1007/s10388-014-0480-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10388-014-0480-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fujiwara Yasuhiro Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Kohata Yukie Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Tanigawa Tetsuya Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Yamagami Hirokazu Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Shiba Masatsugu Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Tominaga Kazunari Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Watanabe Toshio Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Arakawa Tetsuo Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, 545-8585, Osaka, Japan aut NATIONALLICENCE 773 0- Esophagus Springer Japan 12/3(2015-07-01), 244-250 1612-9059 12:3<244 2015 12 10388