caa a22 4500 606204350 CHVBK 20210128101002.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10388-014-0443-7 doi (NATIONALLICENCE)springer-10.1007/s10388-014-0443-7 A case of large cell neuroendocrine carcinoma of the esophagogastric junction [Elektronische Daten] [Minoru Fukuchi, Shinji Sakurai, Ritsuko Tsukagoshi, Hiroshi Naitoh, Hiroyuki Kuwano] Neuroendocrine carcinoma of the upper gastrointestinal tract is an uncommon disease that manifests as a highly malignant tumor. We herein report a rare case of large cell neuroendocrine carcinoma of the esophagogastric junction treated with surgery and chemotherapy. A 65-year-old Japanese man was admitted to our hospital for treatment of a tumor of the esophagogastric junction detected by endoscopic examination. Biopsy specimens demonstrated large cell neuroendocrine carcinoma with highly frequent mitoses and positivity for synaptophysin, chromogranin A, and CD56. Computed tomography indicated at least three lymphadenopathies of the left and right cardiac nodes. We performed distal esophagectomy, total gastrectomy and pancreatosplenectomy, and subsequent S-1 adjuvant chemotherapy, but the patient died of liver metastasis 9months after the surgery. Based on the outcome of the present case, this disease demands establishment of multimodal treatment that includes surgery and chemotherapy. The Japan Esophageal Society and Springer Japan, 2014 Large cell neuroendocrine carcinoma nationallicence Esophagogastric junction nationallicence Chemotherapy nationallicence Fukuchi Minoru Department of Surgery, Gunma Chuo Hospital, 1-7-13 Kouun-cho, 371-0025, Maebashi, Gunma, Japan aut Sakurai Shinji Department of Diagnostic Pathology, Gunma Chuo Hospital, 371-0025, Maebashi, Japan aut Tsukagoshi Ritsuko Department of Surgery, Gunma Chuo Hospital, 1-7-13 Kouun-cho, 371-0025, Maebashi, Gunma, Japan aut Naitoh Hiroshi Department of Surgery, Gunma Chuo Hospital, 1-7-13 Kouun-cho, 371-0025, Maebashi, Gunma, Japan aut Kuwano Hiroyuki Department of General Surgical Science, Gunma University Graduate School of Medicine, 371-8511, Maebashi, Japan aut Esophagus Springer Japan 12/3(2015-07-01), 295-299 1612-9059 12:3<295 2015 12 10388 https://doi.org/10.1007/s10388-014-0443-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10388-014-0443-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fukuchi Minoru Department of Surgery, Gunma Chuo Hospital, 1-7-13 Kouun-cho, 371-0025, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Sakurai Shinji Department of Diagnostic Pathology, Gunma Chuo Hospital, 371-0025, Maebashi, Japan aut NATIONALLICENCE 700 1- Tsukagoshi Ritsuko Department of Surgery, Gunma Chuo Hospital, 1-7-13 Kouun-cho, 371-0025, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Naitoh Hiroshi Department of Surgery, Gunma Chuo Hospital, 1-7-13 Kouun-cho, 371-0025, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Kuwano Hiroyuki Department of General Surgical Science, Gunma University Graduate School of Medicine, 371-8511, Maebashi, Japan aut NATIONALLICENCE 773 0- Esophagus Springer Japan 12/3(2015-07-01), 295-299 1612-9059 12:3<295 2015 12 10388