caa a22 4500 606204423 CHVBK 20210128101002.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10388-014-0477-x doi (NATIONALLICENCE)springer-10.1007/s10388-014-0477-x Risk factors for low response to proton-pump inhibitor treatment in reflux esophagitis and non-erosive reflux disease evaluated by the frequency scale for the symptoms of gastroesophageal reflux disease [Elektronische Daten] [Kayo Akutagawa, Ryuichi Iwakiri, Megumi Hara, Kazuma Fujimoto, Yasuhiro Fujiwara, Masahiko Inamori, Junji Tanaka, Tomohiko Shimatani, Junichi Akiyama, Takashi Ando, Noriaki Manabe, Fukunori Kinjo, Ryuzo Deguchi, Motoyasu Kusano] Background: This study aimed to evaluate risk factors for resistance to proton-pump inhibitor (PPI) therapy among patients with reflux esophagitis (RE) and nonerosive reflux disease (NERD) in gastroesophageal reflux disease (GERD) using a standardized questionnaire in Japan: the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (FSSG). Methods: One hundred fifty-eight patients who underwent upper gastrointestinal endoscopy were enrolled: 87 were diagnosed with RE (mean age: 59.5±15.1years; male/female: 47/39) and 71 with NERD (mean age 53.0±17.6years; male/female 22/49). The patients were divided into two groups according to improvement after PPI treatment evaluated by FSSG: rapid responders were patients with ≥50% improvement according to FSSG, and low responders were those with <50% improvement according to FSSG. All patients were treated with the PPI rabeprazole (10mg/day) for 4weeks. Results: Response rate to PPI therapy was 65.5% (57/87) in RE and 54.9% (39/71) in NERD, indicating that the PPI treatment was more effective for RE. In RE, risk factors for PPI resistance indicated by univariate analysis were low stature and high body mass index. Low stature was a risk factor in multivariate analysis. With regard to NERD, univariate analysis indicated that female gender, high stature, low body weight, and low total FSSG score were risk factors for PPI resistance. Low FSSG score was a risk factor in multivariate analysis. Conclusions: By the present study, we identified the risk factors for PPI resistance in RE and GERD using FSSG. The Japan Esophageal Society and Springer Japan, 2015 Multivariate analysis nationallicence Proton-pump inhibitor nationallicence Questionnaires nationallicence Rabeprazole nationallicence Risk Factors nationallicence Akutagawa Kayo Department of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan aut Iwakiri Ryuichi Department of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan aut Hara Megumi Department of Preventive Medicine, Saga Medical School, Saga, Japan aut Fujimoto Kazuma Department of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan aut Fujiwara Yasuhiro Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan aut Inamori Masahiko Gastroenterology Division, Yokohama City University Hospital, Yokohama, Japan aut Tanaka Junji Division of Upper Gastroenterology, Hyogo College of Medicine, Hyogo, Japan aut Shimatani Tomohiko Department of General Medicine, Hiroshima University Hospital, Hiroshima, Japan aut Akiyama Junichi Department of Gastroenterology, National Center for Global Health and Medicine, Kawasaki, Japan aut Ando Takashi Gastroenterological Department, Kyoto Kuramaguchi Medical Center, Kyoto, Japan aut Manabe Noriaki Division of Endoscopy and Ultrasonography, Kawasaki Medical School, Kurashiki, Japan aut Kinjo Fukunori Department of Endoscopy, University of the Ryukyus, Nishihara, Okinawa, Japan aut Deguchi Ryuzo Department of Internal Medicine, Tokai University School of Medicine, Tokyo, Japan aut Kusano Motoyasu Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Maebashi, Gunma, Japan aut Esophagus Springer Japan 12/3(2015-07-01), 225-232 1612-9059 12:3<225 2015 12 10388 https://doi.org/10.1007/s10388-014-0477-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10388-014-0477-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Akutagawa Kayo Department of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan aut NATIONALLICENCE 700 1- Iwakiri Ryuichi Department of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan aut NATIONALLICENCE 700 1- Hara Megumi Department of Preventive Medicine, Saga Medical School, Saga, Japan aut NATIONALLICENCE 700 1- Fujimoto Kazuma Department of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, 5-1-1 Nabeshima, 849-8501, Saga, Japan aut NATIONALLICENCE 700 1- Fujiwara Yasuhiro Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan aut NATIONALLICENCE 700 1- Inamori Masahiko Gastroenterology Division, Yokohama City University Hospital, Yokohama, Japan aut NATIONALLICENCE 700 1- Tanaka Junji Division of Upper Gastroenterology, Hyogo College of Medicine, Hyogo, Japan aut NATIONALLICENCE 700 1- Shimatani Tomohiko Department of General Medicine, Hiroshima University Hospital, Hiroshima, Japan aut NATIONALLICENCE 700 1- Akiyama Junichi Department of Gastroenterology, National Center for Global Health and Medicine, Kawasaki, Japan aut NATIONALLICENCE 700 1- Ando Takashi Gastroenterological Department, Kyoto Kuramaguchi Medical Center, Kyoto, Japan aut NATIONALLICENCE 700 1- Manabe Noriaki Division of Endoscopy and Ultrasonography, Kawasaki Medical School, Kurashiki, Japan aut NATIONALLICENCE 700 1- Kinjo Fukunori Department of Endoscopy, University of the Ryukyus, Nishihara, Okinawa, Japan aut NATIONALLICENCE 700 1- Deguchi Ryuzo Department of Internal Medicine, Tokai University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Kusano Motoyasu Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Maebashi, Gunma, Japan aut NATIONALLICENCE 773 0- Esophagus Springer Japan 12/3(2015-07-01), 225-232 1612-9059 12:3<225 2015 12 10388