caa a22 4500 606204482 CHVBK 20210128101002.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10388-014-0469-x doi (NATIONALLICENCE)springer-10.1007/s10388-014-0469-x Efficacy of laparoscopic Toupet fundoplication for non-erosive reflux disease assessed by combined multichannel intraluminal impedance-pH monitoring [Elektronische Daten] [Se Yamamoto, Fumiaki Yano, Nobuo Omura, Kazuto Tsuboi, Masato Hoshino, Hideyuki Kashiwagi, Katsuhiko Yanaga] Background: Non-erosive gastroesophageal reflux disease (NERD) is the most common form of gastroesophageal reflux disease (GERD). The aim of this study is to evaluate efficacy of laparoscopic Toupet fundoplication for NERD by combined multichannel intraluminal impedance-pH (MII-pH) monitoring. Methods: Twenty-eight patients who underwent laparoscopic Toupet fundoplication for NERD had MII-pH monitoring before surgery. Among them, 11 patients accepted to undergo MII-pH monitoring both before and after surgery. Their clinical data were collected in a prospective fashion and retrospectively reviewed. Patients' characteristics, the esophageal function of time pH below 4, DeMeester score, the numbers of acid and nonacid reflux episodes and symptom index (SI) were evaluated. Results: Pre- and postoperative time pH below 4 were 5.8±7.1 and 0.7±1.3, respectively, and DeMeester score was 19.7±23.3 and 2.8±3.8, respectively, both of which were significantly different (p=0.022 and 0.019). Pre- and postoperative numbers of all reflux episodes were 84.3±52.5 and 36.2±22.8, respectively. Pre- and postoperative acid reflux episodes were 39.5±35.2 and 9.9±19.2, respectively. There were significant differences in the number of both all and acid reflux episodes (p=0.001 and 0.012). Those of nonacid reflux episodes were 44.8±37.4 and 26.3±13.9, respectively, which did not achieve statistical significance (p=0.068). Six patients (54.5%) had positive SI preoperatively, but no one had positive SI after surgery. Conclusion: Laparoscopic Toupet fundoplication can control gastroesophageal reflux events in patients with NERD. The Japan Esophageal Society and Springer Japan, 2014 Non-erosive gastroesophageal reflux disease nationallicence NERD nationallicence Antirelux surgery nationallicence Laparoscopic fundoplication nationallicence MII-pH nationallicence Yamamoto Se Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-Ku, 105-8461, Tokyo, Japan aut Yano Fumiaki Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-Ku, 105-8461, Tokyo, Japan aut Omura Nobuo Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-Ku, 105-8461, Tokyo, Japan aut Tsuboi Kazuto Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-Ku, 105-8461, Tokyo, Japan aut Hoshino Masato Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-Ku, 105-8461, Tokyo, Japan aut Kashiwagi Hideyuki Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-Ku, 105-8461, Tokyo, Japan aut Yanaga Katsuhiko Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-Ku, 105-8461, Tokyo, Japan aut Esophagus Springer Japan 12/3(2015-07-01), 219-224 1612-9059 12:3<219 2015 12 10388 https://doi.org/10.1007/s10388-014-0469-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10388-014-0469-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamamoto Se Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-Ku, 105-8461, Tokyo, Japan aut NATIONALLICENCE 700 1- Yano Fumiaki Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-Ku, 105-8461, Tokyo, Japan aut NATIONALLICENCE 700 1- Omura Nobuo Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-Ku, 105-8461, Tokyo, Japan aut NATIONALLICENCE 700 1- Tsuboi Kazuto Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-Ku, 105-8461, Tokyo, Japan aut NATIONALLICENCE 700 1- Hoshino Masato Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-Ku, 105-8461, Tokyo, Japan aut NATIONALLICENCE 700 1- Kashiwagi Hideyuki Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-Ku, 105-8461, Tokyo, Japan aut NATIONALLICENCE 700 1- Yanaga Katsuhiko Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-Ku, 105-8461, Tokyo, Japan aut NATIONALLICENCE 773 0- Esophagus Springer Japan 12/3(2015-07-01), 219-224 1612-9059 12:3<219 2015 12 10388