caa a22 4500 606204547 CHVBK 20210128101003.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10388-014-0472-2 doi (NATIONALLICENCE)springer-10.1007/s10388-014-0472-2 Malignant granular cell tumor of the cervical esophagus with loco-regional lymph node metastases [Elektronische Daten] [M. Virginia Barrios, Isidro Machado, Estanislao Arana, Angel Pla, Simon Brotons, Eduardo Ferrandis, Julia Cruz, Javier Lavernia, María Chust, Juan Vendrell] Granular cell tumors (GCTs) are uncommon, mostly benign lesions. The malignant form and involvement of the cervical esophagus are rare. A 53-year-old female was referred to our hospital for treatment of a malignant cervical esophageal GCT. We performed a pharyngolaryngeal esophagectomy, total thyroidectomy and selective bilateral neck lymph node dissection. Histopathology revealed a malignant GCT involving cervical esophagus. S100, CD56, inhibin and PGP9.5 proteins were positive and the surgical margins were negative. Metastatic disease in 6 loco-regional lymph nodes and focal infiltration in tracheal tissue were detected. To the best of our knowledge, this is the first case of malignant GCT arising in cervical esophagus showing loco-regional lymph node metastases. At present the patient is free of disease 7months after surgery. The Japan Esophageal Society and Springer Japan, 2014 Malignant granular cell tumor nationallicence Cervical esophagus nationallicence Immunohistochemistry nationallicence Metastasis nationallicence Virginia Barrios M. Otorhinolaryngology Department, General Hospital Castellon, Castellon, Spain aut Machado Isidro Pathology Department, Instituto Valenciano de Oncología, Avda. Gregorio Gea 31, CP 46009, Valencia, Spain aut Arana Estanislao Radiology Department, Instituto Valenciano de Oncología, Valencia, Spain aut Pla Angel Otorhinolaryngology Department, Instituto Valenciano de Oncología, Valencia, Spain aut Brotons Simon Otorhinolaryngology Department, Instituto Valenciano de Oncología, Valencia, Spain aut Ferrandis Eduardo Otorhinolaryngology Department, Instituto Valenciano de Oncología, Valencia, Spain aut Cruz Julia Pathology Department, Instituto Valenciano de Oncología, Avda. Gregorio Gea 31, CP 46009, Valencia, Spain aut Lavernia Javier Oncology Department, Instituto Valenciano de Oncología, Valencia, Spain aut Chust María Radiotherapy Department, Instituto Valenciano de Oncología, Valencia, Spain aut Vendrell Juan Otorhinolaryngology Department, Instituto Valenciano de Oncología, Valencia, Spain aut Esophagus Springer Japan 12/4(2015-10-01), 377-382 1612-9059 12:4<377 2015 12 10388 https://doi.org/10.1007/s10388-014-0472-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10388-014-0472-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Virginia Barrios M. Otorhinolaryngology Department, General Hospital Castellon, Castellon, Spain aut NATIONALLICENCE 700 1- Machado Isidro Pathology Department, Instituto Valenciano de Oncología, Avda. Gregorio Gea 31, CP 46009, Valencia, Spain aut NATIONALLICENCE 700 1- Arana Estanislao Radiology Department, Instituto Valenciano de Oncología, Valencia, Spain aut NATIONALLICENCE 700 1- Pla Angel Otorhinolaryngology Department, Instituto Valenciano de Oncología, Valencia, Spain aut NATIONALLICENCE 700 1- Brotons Simon Otorhinolaryngology Department, Instituto Valenciano de Oncología, Valencia, Spain aut NATIONALLICENCE 700 1- Ferrandis Eduardo Otorhinolaryngology Department, Instituto Valenciano de Oncología, Valencia, Spain aut NATIONALLICENCE 700 1- Cruz Julia Pathology Department, Instituto Valenciano de Oncología, Avda. Gregorio Gea 31, CP 46009, Valencia, Spain aut NATIONALLICENCE 700 1- Lavernia Javier Oncology Department, Instituto Valenciano de Oncología, Valencia, Spain aut NATIONALLICENCE 700 1- Chust María Radiotherapy Department, Instituto Valenciano de Oncología, Valencia, Spain aut NATIONALLICENCE 700 1- Vendrell Juan Otorhinolaryngology Department, Instituto Valenciano de Oncología, Valencia, Spain aut NATIONALLICENCE 773 0- Esophagus Springer Japan 12/4(2015-10-01), 377-382 1612-9059 12:4<377 2015 12 10388