caa a22 4500 606204571 CHVBK 20210128101003.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10388-014-0482-0 doi (NATIONALLICENCE)springer-10.1007/s10388-014-0482-0 Prognostic significance of circulating tumor cells in patients with advanced esophageal cancer [Elektronische Daten] [Motomu Tanaka, Hiroya Takeuchi, Yoshiki Osaki, Kunihiko Hiraiwa, Rieko Nakamura, Takashi Oyama, Tsunehiro Takahashi, Norihito Wada, Hirofumi Kawakubo, Yoshiro Saikawa, Tai Omori, Yuko Kitagawa] Introduction: The purpose of this study was to establish the clinicopathological significance of circulating tumor cells (CTCs) in patients with advanced or recurrent esophageal cancer who received either chemotherapy or chemoradiotherapy. Methods: CTCs from 38 patients with advanced or recurrent esophageal cancer were quantified using the CellSearch system before and approximately 3-5weeks after the initiation of a new line of chemotherapy or chemoradiotherapy. The correlation between CTC counts and clinicopathological variables was examined. Results: Of the 38 patients, 15 (39%) had recurrent esophageal cancer, and 23 patients (61%) had primary advanced esophageal cancer. The mean age was 63years (range 43-87years). One patient (2.6%) had a complete response to treatment, 16 (42.1%) had a partial response, 12 (31.6%) showed stable disease, and nine (23.7%) showed signs of progressive disease. The overall survival of patients with ≥2 CTCs was significantly shorter than that of patients with <2 CTCs both at baseline and at first follow-up (p=0.047 and p=0.011, respectively). Significant correlation was found between the change in CTC counts and the response to treatment (p=0.036). The overall survival in patients with ≥2 CTCs both at baseline and at first follow-up was significantly shorter than patients with <2 CTCs both at baseline and at first follow-up (p=0.002). Patients with a reduction rate in the CTC value <80% experienced significantly shorter survival than patients with a reduction rate of ≥80% (p=0.035). The CTC counts at first follow-up served as an independent prognostic factor (p=0.011). Conclusions: Our results suggest that measuring the number of CTCs in patients with advanced or recurrent esophageal cancer can be useful for predicting the survival of patients and for monitoring the response to cancer treatments. The Japan Esophageal Society and Springer Japan, 2014 Circulating tumor cells nationallicence Esophageal cancer nationallicence CellSearch system nationallicence Tanaka Motomu Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Takeuchi Hiroya Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Osaki Yoshiki Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Hiraiwa Kunihiko Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Nakamura Rieko Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Oyama Takashi Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Takahashi Tsunehiro Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Wada Norihito Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Kawakubo Hirofumi Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Saikawa Yoshiro Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Omori Tai Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Kitagawa Yuko Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut Esophagus Springer Japan 12/4(2015-10-01), 352-359 1612-9059 12:4<352 2015 12 10388 https://doi.org/10.1007/s10388-014-0482-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10388-014-0482-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tanaka Motomu Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Takeuchi Hiroya Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Osaki Yoshiki Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Hiraiwa Kunihiko Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakamura Rieko Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Oyama Takashi Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Takahashi Tsunehiro Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Wada Norihito Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Kawakubo Hirofumi Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Saikawa Yoshiro Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Omori Tai Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 700 1- Kitagawa Yuko Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan aut NATIONALLICENCE 773 0- Esophagus Springer Japan 12/4(2015-10-01), 352-359 1612-9059 12:4<352 2015 12 10388