caa a22 4500 606204725 CHVBK 20210128101004.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10388-015-0484-6 doi (NATIONALLICENCE)springer-10.1007/s10388-015-0484-6 Esophageal malignant melanoma: analysis of 134 cases collected by the Japan Esophageal Society [Elektronische Daten] [Hiroyasu Makuuchi, Kaiyo Takubo, Akio Yanagisawa, Soichiro Yamamoto] Background: Esophageal malignant melanoma is an extremely rare disease and no scientific society has systematically collected data on it previously. Method: The 141 institutes belonging to the Japan Esophageal Society conducted a questionnaire on the details of esophageal malignant melanoma during the 10-year period from 1998 to 2007. Results: The questionnaire return rate was 92.9%. In the 10-year period, there were 134 cases of the disease, indicating an incidence of about 13-14 cases per year in Japan. Of these, 70 cases (52.2%) had invasion extending up to the submucosal layer, while 64 cases (47.8%) were advanced malignant melanoma. There were 84 cases (62.7%) of lymph node metastasis and, of these, 25 cases (18.7%) showed metastasis to distant organs. Endoscopic resection was performed in 7 cases (5.2%) and surgical resection alone and surgery plus chemotherapy were employed in 102 cases (76.1%), 21 cases (15.7%) received chemotherapy or chemoradiotherapy and 4 cases received best supportive care. Of these, 53 cases died within 1 year and the 1-, 3-, 5-year survival rates by the Kaplan-Meier method were 56.9, 28.0 and 26.3%, respectively. Of the 13 cases surviving 5years or more, 12 were superficial malignant melanoma and 8 had lymph node metastasis. Conclusion: In principle, the treatment of esophageal malignant melanoma consists of surgical resection, but its indications and adjuvant therapy with new drugs require an extremely thorough rethinking in terms of therapeutic strategy. The Japan Esophageal Society and Springer Japan, 2015 Esophageal malignant melanoma nationallicence Survival rate nationallicence Treatment nationallicence Superficial malignant melanoma nationallicence Makuuchi Hiroyasu Department of Gastroenterological Surgery, School of Medicine, Tokai University, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan aut Takubo Kaiyo Genome Analysis Team, Tokyo Metropolitan Geriatric Research Institute, 35-2 Sakaecho, Itabashi-ku, 175-0015, Tokyo, Japan aut Yanagisawa Akio Department of Pathology, Kyoto Prefectural University, 465 Kajiicho, Kawaramachidorihirokojiagaru, Kamigyo-ku, 602-8566, Kyoto, Japan aut Yamamoto Soichiro Department of Gastroenterological Surgery, School of Medicine, Tokai University, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan aut Esophagus Springer Japan 12/2(2015-04-01), 158-169 1612-9059 12:2<158 2015 12 10388 https://doi.org/10.1007/s10388-015-0484-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10388-015-0484-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Makuuchi Hiroyasu Department of Gastroenterological Surgery, School of Medicine, Tokai University, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan aut NATIONALLICENCE 700 1- Takubo Kaiyo Genome Analysis Team, Tokyo Metropolitan Geriatric Research Institute, 35-2 Sakaecho, Itabashi-ku, 175-0015, Tokyo, Japan aut NATIONALLICENCE 700 1- Yanagisawa Akio Department of Pathology, Kyoto Prefectural University, 465 Kajiicho, Kawaramachidorihirokojiagaru, Kamigyo-ku, 602-8566, Kyoto, Japan aut NATIONALLICENCE 700 1- Yamamoto Soichiro Department of Gastroenterological Surgery, School of Medicine, Tokai University, 143 Shimokasuya, 259-1193, Isehara, Kanagawa, Japan aut NATIONALLICENCE 773 0- Esophagus Springer Japan 12/2(2015-04-01), 158-169 1612-9059 12:2<158 2015 12 10388