caa a22 4500 606204733 CHVBK 20210128101004.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10388-014-0460-6 doi (NATIONALLICENCE)springer-10.1007/s10388-014-0460-6 Preoperative chemoradiotherapy with docetaxel, doxifluridine, and low-dose cisplatin for stage II/III squamous cell carcinoma of the esophagus [Elektronische Daten] [Yasuhiro Yuasa, Hiroshi Okitsu, Masakazu Goto, Hiroshi Edagawa, Osamu Mori, Ryotaro Tani, Atsushi Tomibayashi, Daisuke Matsumoto, Syunsuke Kuramoto, Kyosuke Osaki] Background: Preoperative chemotherapy using 5-fluorouracil and cisplatin is a standard treatment for stage II/III esophageal squamous cell carcinoma (ESCC) in Japan. However, stronger therapies are needed for advanced ESCC. This retrospective study aimed to evaluate the feasibility and safety of neoadjuvant chemoradiotherapy with R-DDP. Methods: Patients diagnosed with clinical stage II/III ESCC and initially treated with preoperative R-DDP were enrolled. R-DDP comprised intravenous docetaxel (40mgm−2day−1 on day 1), oral doxifluridine (800mgm−2day−1 on days 1-7), low-dose cisplatin (5mgm−2day−1 on days 1-5), and concurrent radiation (2Gyday−1 on days 1-5), which were repeated weekly for 3weeks (maximum total radiation: 30Gy). If clinical stage T4 was suspected, another week of the regimen was added (maximum total radiation: 40Gy). After therapy evaluation, patients underwent esophagectomy with 2 or 3 fields of lymphadenectomy. Results: Between April 2003 and March 2011, 19 eligible patients were enrolled (treatment completion rate: 89.5%). Complete or partial response was obtained in 17 cases (89.5%), and 8 cases (42.1%) involved downstaging. In resected specimens, the primary tumor's histopathological grade was 1, 2, and 3 in 3, 11, and 5 cases. Although 42.1% of patients developed grade 3+ adverse events, there were no severe perioperative complications. Three- and five-year overall survival rates were 42.1 and 36.1%, with a 23-month median progression-free survival. Conclusions: Although this treatment had good antitumor effects, it did not necessarily confer prognostic improvements. R-DDP could become a therapeutic strategy for locally advanced ESCC. The Japan Esophageal Society and Springer Japan, 2014 Esophageal cancer nationallicence Chemoradiotherapy nationallicence Neoadjuvant therapy nationallicence Yuasa Yasuhiro Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut Okitsu Hiroshi Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut Goto Masakazu Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut Edagawa Hiroshi Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut Mori Osamu Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut Tani Ryotaro Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut Tomibayashi Atsushi Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut Matsumoto Daisuke Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut Kuramoto Syunsuke Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut Osaki Kyosuke Department of Radiology, Tokushima Red Cross Hospital, Komatsushima, Japan aut Esophagus Springer Japan 12/2(2015-04-01), 191-198 1612-9059 12:2<191 2015 12 10388 https://doi.org/10.1007/s10388-014-0460-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10388-014-0460-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yuasa Yasuhiro Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut NATIONALLICENCE 700 1- Okitsu Hiroshi Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut NATIONALLICENCE 700 1- Goto Masakazu Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut NATIONALLICENCE 700 1- Edagawa Hiroshi Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut NATIONALLICENCE 700 1- Mori Osamu Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut NATIONALLICENCE 700 1- Tani Ryotaro Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut NATIONALLICENCE 700 1- Tomibayashi Atsushi Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut NATIONALLICENCE 700 1- Matsumoto Daisuke Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut NATIONALLICENCE 700 1- Kuramoto Syunsuke Department of Digestive Surgery, Tokushima Red Cross Hospital, 103 Irinokuchi, Komatsushima-cho, 773-8502, Komatsushima, Tokushima, Japan aut NATIONALLICENCE 700 1- Osaki Kyosuke Department of Radiology, Tokushima Red Cross Hospital, Komatsushima, Japan aut NATIONALLICENCE 773 0- Esophagus Springer Japan 12/2(2015-04-01), 191-198 1612-9059 12:2<191 2015 12 10388