caa a22 4500 606206914 CHVBK 20210128101013.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10353-015-0352-6 doi (NATIONALLICENCE)springer-10.1007/s10353-015-0352-6 The role of platelets and portal venous pressure fluctuations in postoperative liver regeneration [Elektronische Daten] [P. Starlinger, A. Assinger, T. Gruenberger, C. Brostjan] Summary: Background: The most relevant factor predicting morbidity and mortality after liver resection is the ability of the remnant liver to regenerate. In line with extensive experimental research, we were recently able to demonstrate that serotonin and thrombospondin-1, two factors abundantly stored in platelets, are closely associated with liver regeneration of patients after liver resection. Methods: Within this review, we summarized existing evidence regarding the relevance of platelets in liver regeneration. Results: We illustrated a potential interaction of platelet activation and its relation to portal venous pressure during the process of liver regeneration. Conclusions: We are able to explore possible effects of specific granule release as a key regulator to allow for platelet-induced liver regeneration. As a second objective, we discussed postoperative portal venous pressure as a potential mechanism and initiating effect in postoperative platelet activation during liver regeneration which may offer new therapeutic targets to promote postoperative liver regeneration. Springer-Verlag Wien, 2015 Liver regeneration nationallicence Platelets nationallicence Platelet activation nationallicence Alpha-granula nationallicence Portal venous pressure nationallicence Starlinger P. Department of Surgery, Medical University of Vienna, General Hospital, Waehringer Guertel 18-20, 1090, Vienna, Austria aut Assinger A. Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria aut Gruenberger T. Department of Surgery I, Rudolfstiftung Hospital, Vienna, Austria aut Brostjan C. Department of Surgery, Medical University of Vienna, General Hospital, Waehringer Guertel 18-20, 1090, Vienna, Austria aut European Surgery Springer Vienna 47/6(2015-12-01), 312-318 1682-8631 47:6<312 2015 47 10353 https://doi.org/10.1007/s10353-015-0352-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10353-015-0352-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Starlinger P. Department of Surgery, Medical University of Vienna, General Hospital, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Assinger A. Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Gruenberger T. Department of Surgery I, Rudolfstiftung Hospital, Vienna, Austria aut NATIONALLICENCE 700 1- Brostjan C. Department of Surgery, Medical University of Vienna, General Hospital, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 773 0- European Surgery Springer Vienna 47/6(2015-12-01), 312-318 1682-8631 47:6<312 2015 47 10353