caa a22 4500 606207058 CHVBK 20210128101014.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10353-015-0312-1 doi (NATIONALLICENCE)springer-10.1007/s10353-015-0312-1 Surgical intervention does not affect short-term plasma citrulline levels in infants: implications for citrulline as a marker of postoperative intestinal complications [Elektronische Daten] [G. Frongia, S. Weih, P. Romero, A. Mehrabi, S. Holland-Cunz, P. Günther] Summary: Background and aims: Detection of intestinal ischemia is often delayed causing extensive complications. Serum citrulline is an important parameter for bowel integrity and functionality; however, no data is available on its response on postoperative intestinal impairment in children. The aim of this study was to evaluate the native effects of intestinal surgery on the postoperative citrulline course in children. Material and methods: In two groups, of each five children under the age of 2, undergoing either intestinal surgery (IS) or non-intestinal surgery (NIS), we monitored unspecific intestinal impairment parameters (lactate, C-reactive protein (CRP), leukocytes) and citrulline prior to surgery and on the 3rd postoperative day. Results: In both groups the postoperative course was uneventful, including unproblematic transition to a normal diet and regular stool. Postoperatively, CRP levels were slightly increased (IS p > 0.05; NIS p < 0.05) while leukocytes and lactate levels did not show any significant changes. The citrulline levels remained constant in the perioperative period. Conclusions: This data suggests that IS does not affect perioperative citrulline levels in children under the age of 2 years with uneventful postoperative course. Changes in citrulline following surgery might be a sign of intestinal impairment and therefore further investigations are necessary on this field. Springer-Verlag Wien, 2015 Citrulline nationallicence Intestinal surgery nationallicence Intestinal ischemia nationallicence Intestinal impairment nationallicence Intestinal marker nationallicence Children nationallicence Frongia G. Division of Pediatric Surgery, Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany aut Weih S. Department of Pediatric Surgery, University Children's Hospital, Basel, Switzerland aut Romero P. Division of Pediatric Surgery, Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany aut Mehrabi A. Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany aut Holland-Cunz S. Department of Pediatric Surgery, University Children's Hospital, Basel, Switzerland aut Günther P. Division of Pediatric Surgery, Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany aut European Surgery Springer Vienna 47/3(2015-06-01), 107-111 1682-8631 47:3<107 2015 47 10353 https://doi.org/10.1007/s10353-015-0312-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10353-015-0312-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Frongia G. Division of Pediatric Surgery, Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Weih S. Department of Pediatric Surgery, University Children's Hospital, Basel, Switzerland aut NATIONALLICENCE 700 1- Romero P. Division of Pediatric Surgery, Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Mehrabi A. Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany aut NATIONALLICENCE 700 1- Holland-Cunz S. Department of Pediatric Surgery, University Children's Hospital, Basel, Switzerland aut NATIONALLICENCE 700 1- Günther P. Division of Pediatric Surgery, Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany aut NATIONALLICENCE 773 0- European Surgery Springer Vienna 47/3(2015-06-01), 107-111 1682-8631 47:3<107 2015 47 10353