caa a22 4500 606207066 CHVBK 20210128101014.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10353-015-0317-9 doi (NATIONALLICENCE)springer-10.1007/s10353-015-0317-9 Significant relationship between preoperative serum concentration of anti-heat shock protein 70 antibody and postoperative morbidity in patients with esophageal cancer [Elektronische Daten] [M. Nakajima, H. Kato, M. Sakai, A. Sano, T. Miyazaki, M. Sohda, T. Inose, T. Yokobori, N. Tanaka, S. Suzuki, N. Masuda, M. Fukuchi, H. Kuwano] Summary: Background: Heat shock protein 70 is a molecular chaperone important in host responses to stress, including infection, injury, oxidative damage, hypoxia, and thermal stress. This study analyzed the correlation between preoperative serum concentrations of anti-HPS70 antibody and postoperative morbidity in patients with esophageal cancer. Materials and methods: Serum samples were obtained preoperatively from 50 esophageal carcinoma patients (46 men and 4 women) who underwent potentially curative surgery without preoperative therapy. Serum anti-HSP70 antibody concentrations were measured by enzyme-linked immunosorbent assays. Results: The mean concentration of anti-HSP70 antibody was 187.0μg/mL. When patients were dichotomized relative to this cutoff, we observed no significant relationships between perioperative inflammatory markers (maximum body temperature, white blood cell count and C-reactive protein concentration) and anti-HSP70 antibody concentration. The incidence of postoperative complications was significantly lower in patients with anti-HSP ≥ 187.0μg/mL than < 187.0μg/mL (p = 0.0336). Conclusions: Preoperative serum concentration of anti-HSP70 antibody was significantly related to postoperative morbidities in patients with esophageal cancer. Springer-Verlag Wien, 2015 Esophageal cancer nationallicence Esophagectomy nationallicence Morbidity nationallicence Anti-HSP70 antibody nationallicence HSP70 nationallicence Nakajima M. Department of Surgery I, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Shimotsuga-gun, Tochigi, Japan aut Kato H. Department of Surgery I, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Shimotsuga-gun, Tochigi, Japan aut Sakai M. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut Sano A. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut Miyazaki T. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut Sohda M. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut Inose T. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut Yokobori T. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut Tanaka N. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut Suzuki S. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut Masuda N. Department of Surgery, National Hospital Organization, Utsunomiya National Hospital, 329-1193, Utsunomiya, Tochigi, Japan aut Fukuchi M. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut Kuwano H. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut European Surgery Springer Vienna 47/3(2015-06-01), 117-122 1682-8631 47:3<117 2015 47 10353 https://doi.org/10.1007/s10353-015-0317-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10353-015-0317-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakajima M. Department of Surgery I, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Shimotsuga-gun, Tochigi, Japan aut NATIONALLICENCE 700 1- Kato H. Department of Surgery I, Dokkyo Medical University, 880 Kitakobayashi, 321-0293, Mibu, Shimotsuga-gun, Tochigi, Japan aut NATIONALLICENCE 700 1- Sakai M. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut NATIONALLICENCE 700 1- Sano A. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut NATIONALLICENCE 700 1- Miyazaki T. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut NATIONALLICENCE 700 1- Sohda M. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut NATIONALLICENCE 700 1- Inose T. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut NATIONALLICENCE 700 1- Yokobori T. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut NATIONALLICENCE 700 1- Tanaka N. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut NATIONALLICENCE 700 1- Suzuki S. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut NATIONALLICENCE 700 1- Masuda N. Department of Surgery, National Hospital Organization, Utsunomiya National Hospital, 329-1193, Utsunomiya, Tochigi, Japan aut NATIONALLICENCE 700 1- Fukuchi M. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut NATIONALLICENCE 700 1- Kuwano H. Department of General Surgical Science (Surgery I), Graduate School of Medicine, Gunma University, 371-8511, Maebashi, Japan aut NATIONALLICENCE 773 0- European Surgery Springer Vienna 47/3(2015-06-01), 117-122 1682-8631 47:3<117 2015 47 10353