caa a22 4500 606207236 CHVBK 20210128101015.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10353-015-0344-6 doi (NATIONALLICENCE)springer-10.1007/s10353-015-0344-6 Galectin-3 as a potential biomarker in colorectal cancer? [Elektronische Daten] [S. Kamali, E. Yilmaz, E. Sivrikoz, M. O. Erturk, G. H. Kamali, T. S. Sivrikoz, H. Guven] Summary: Background: Colorectal cancer incidence is inclining in the past decades, and diagnosis relies mainly on colonoscopic screening. Galectin-3 is recently shown to be associated with colorectal cancer. This study aimed to correlate serum galectin-3 levels with pathologically proven colorectal cancer. Methods: All adult patients diagnosed with colorectal cancer in our institution from January to March 2013 were included in this prospective, observational study. During the same period, a control group with normal colonoscopic findings were included. After inclusion into the study, blood samples were collected from all participants. Serums obtained from the samples were stored at − 20 °C. Galectin-3 levels in blood samples were measured with an in vitro cantitative enzyme-linked immunosorbent assay (ELISA). Results: Mean age was 62.7 years (range 29-85; standard deviation (SD): 14.8), mean body mass index (BMI) was 26.4 (21.4-42.4; SD: 4.5). Obesity (BMI ≤ 30), advanced age (≥55 years), and male gender were not significantly different among study groups (p > 0.05). In the colorectal cancer group mean galectin-3 levels were significantly elevated as compared to their control group counterparts (125.2 ± 19.1 vs. 23.0 ± 10.2, p < 0.001). Conclusions: Galectin-3 levels were found significantly increased in colorectal cancer patients when compared with healthy controls. Further research is warranted to investigate the prognostic potential of galectin-3 in colorectal cancer. Springer-Verlag Wien, 2015 Galectin-3 nationallicence Colon cancer nationallicence Diagnosis nationallicence Kamali S. Department of General Surgery, Okmeydani Training and Research Hospital, Darulaceze Cad., 25, 34384, Istanbul, Turkey aut Yilmaz E. Department of General Surgery, Okmeydani Training and Research Hospital, Darulaceze Cad., 25, 34384, Istanbul, Turkey aut Sivrikoz E. Department of General Surgery, Okmeydani Training and Research Hospital, Darulaceze Cad., 25, 34384, Istanbul, Turkey aut Erturk M. O. Department of General Surgery, Okmeydani Training and Research Hospital, Darulaceze Cad., 25, 34384, Istanbul, Turkey aut Kamali G. H. Department of Pathology, Okmeydani Training and Research Hospital, Istanbul, Turkey aut Sivrikoz T. S. Division of Perinatology, Department of Obstetrics and Gynecology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey aut Guven H. Department of General Surgery, Okmeydani Training and Research Hospital, Darulaceze Cad., 25, 34384, Istanbul, Turkey aut European Surgery Springer Vienna 47/5(2015-10-01), 254-257 1682-8631 47:5<254 2015 47 10353 https://doi.org/10.1007/s10353-015-0344-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10353-015-0344-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kamali S. Department of General Surgery, Okmeydani Training and Research Hospital, Darulaceze Cad., 25, 34384, Istanbul, Turkey aut NATIONALLICENCE 700 1- Yilmaz E. Department of General Surgery, Okmeydani Training and Research Hospital, Darulaceze Cad., 25, 34384, Istanbul, Turkey aut NATIONALLICENCE 700 1- Sivrikoz E. Department of General Surgery, Okmeydani Training and Research Hospital, Darulaceze Cad., 25, 34384, Istanbul, Turkey aut NATIONALLICENCE 700 1- Erturk M. O. Department of General Surgery, Okmeydani Training and Research Hospital, Darulaceze Cad., 25, 34384, Istanbul, Turkey aut NATIONALLICENCE 700 1- Kamali G. H. Department of Pathology, Okmeydani Training and Research Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Sivrikoz T. S. Division of Perinatology, Department of Obstetrics and Gynecology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey aut NATIONALLICENCE 700 1- Guven H. Department of General Surgery, Okmeydani Training and Research Hospital, Darulaceze Cad., 25, 34384, Istanbul, Turkey aut NATIONALLICENCE 773 0- European Surgery Springer Vienna 47/5(2015-10-01), 254-257 1682-8631 47:5<254 2015 47 10353