caa a22 4500 606207279 CHVBK 20210128101015.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10353-015-0330-z doi (NATIONALLICENCE)springer-10.1007/s10353-015-0330-z Transanal endoscopic microsurgery in treatment of small rectal T1 high-risk, T2 and T3 carcinomas combined with radiochemotherapy [Elektronische Daten] [M. Amann, J. Burghardt, C. Stratz, G. F. Buess, A. Modabber] Summary: Background: The present survey evaluates the value of TEM in the treatment of small T1 high-risk, T2 and T3 carcinomas in combination with neoadjuvant or adjuvant therapy or without radiochemotherapy. Methods: In this retrospective survey, patient data from 86 patients suffering from T1 high-risk, T2 or T3 carcinoma was reviewed. Results: Overall, Patients with T1 high-risk carcinoma showed a recurrence rate of 12.5 % (n = 16). The recurrence rate of T2 low-risk carcinomas was 11.1 % (n = 36), and of T2 high-risk carcinomas was 31.3 % (n = 17). Patients who had suffered a T3 low-risk carcinoma showed a recurrence rate of 0 % (n = 5). In the group of patients with T3 high-risk carcinomas, 16.7 % (n = 12) showed a recurrence. Conclusions: An analysis of the different subgroups has shown that after successful downstaging with neoadjuvant radiochemotherapy, TEM is a curative treatment alternative for T2 low-risk carcinomas. It seems that the degree of downstaging has an effect on the prognosis with regard to the appearance of a local recurrence. The effect of downstaging of T2 low risk carcinomas can possibly be applied to T3 low-risk carcinomas. In the case of high-risk carcinomas, TEM can only be a treatment alternative for comorbid patients or a method for palliation. Springer-Verlag Wien, 2015 TEM nationallicence Rectal carcinoma nationallicence Local surgery nationallicence Amann M. Department of Cardiology, University Heart Center Freiburg/Bad Krozingen, Südring 15, 79189, Bad Krozingen, Germany aut Burghardt J. Department of Surgery, Freikirchliches Krankenhaus und Poliklinik Rüdersdorf, Rüdersdorf, Germany aut Stratz C. Department of Cardiology, University Heart Center Freiburg/Bad Krozingen, Südring 15, 79189, Bad Krozingen, Germany aut Buess G. F. Department of General, Visceral and Transplant Surgery, Tübingen University Hospital, Tübingen, Germany aut Modabber A. Department of Oral, Maxillofacial and Plastic Facial Surgery, Aachen University Hospital, Aachen, Germany aut European Surgery Springer Vienna 47/5(2015-10-01), 226-237 1682-8631 47:5<226 2015 47 10353 https://doi.org/10.1007/s10353-015-0330-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10353-015-0330-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Amann M. Department of Cardiology, University Heart Center Freiburg/Bad Krozingen, Südring 15, 79189, Bad Krozingen, Germany aut NATIONALLICENCE 700 1- Burghardt J. Department of Surgery, Freikirchliches Krankenhaus und Poliklinik Rüdersdorf, Rüdersdorf, Germany aut NATIONALLICENCE 700 1- Stratz C. Department of Cardiology, University Heart Center Freiburg/Bad Krozingen, Südring 15, 79189, Bad Krozingen, Germany aut NATIONALLICENCE 700 1- Buess G. F. Department of General, Visceral and Transplant Surgery, Tübingen University Hospital, Tübingen, Germany aut NATIONALLICENCE 700 1- Modabber A. Department of Oral, Maxillofacial and Plastic Facial Surgery, Aachen University Hospital, Aachen, Germany aut NATIONALLICENCE 773 0- European Surgery Springer Vienna 47/5(2015-10-01), 226-237 1682-8631 47:5<226 2015 47 10353