caa a22 4500 606207317 CHVBK 20210128101016.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10353-015-0342-8 doi (NATIONALLICENCE)springer-10.1007/s10353-015-0342-8 The assay and clinical significance of serum thymidine kinase 1 in patients with colorectal carcinoma [Elektronische Daten] [Y. Zhang, J. Wang, J. Xie, D. Yang, G. Han, Y. Zhang, Q. Fu] Summary: Background: Thymidine kinase 1 was regarded as a good serological marker for cell proliferation. In recent years, the role of thymidine kinase 1 in occurrence, development, and prognosis of tumors gradually attracted people's attention and had been regarded as a sensitive indicator of tumor. The aim of the present study was to investigate the clinical value of detection of serum thymidine kinase 1 in colorectal carcinoma. Methods: In this study, the level of serum thymidine kinase 1 in 150 patients with colorectal carcinoma, 36 patients with benign colorectal diseases, and 40 normal controls was determined by a chemiluminescence dot blot assay. Results: The level of serum thymidine kinase 1 in patients with colorectal carcinoma was much higher than that in patients with benign colorectal diseases and normal controls (P < 0.01), but there was no significant difference between the level of serum thymidine kinase 1 in patients with benign colorectal diseases and that in normal controls (P > 0.05). The level of serum thymidine kinase 1 declined significantly 1 month after operation. The positive rate of serum thymidine kinase 1 in patients with colorectal carcinoma was much higher than other digestive tumor markers [carcinoembryonic antigen (CEA), carbohydrate antigen (CA-199, CA-724)]. Conclusions: The detection of serum thymidine kinase 1 might have high clinical value in auxiliary diagnosis, curative effect monitoring, and prognosis judgment of colorectal carcinoma. Springer-Verlag Wien, 2015 Thymidine kinase 1 nationallicence Colorectal carcinoma nationallicence Tumor marker nationallicence Zhang Y. Department of Surgery, First Affiliated Hospital of Zhengzhou University, No. 54, Building 10, No.2 Huanghe Road, 450008, Zhengzhou City, Henan Province, P. R. China aut Wang J. Department of Surgery, First Affiliated Hospital of Zhengzhou University, No. 54, Building 10, No.2 Huanghe Road, 450008, Zhengzhou City, Henan Province, P. R. China aut Xie J. Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, Zhengzhou, China aut Yang D. Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, USA aut Han G. Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, Zhengzhou, China aut Zhang Y. Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, Zhengzhou, China aut Fu Q. Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, Zhengzhou, China aut European Surgery Springer Vienna 47/5(2015-10-01), 248-253 1682-8631 47:5<248 2015 47 10353 https://doi.org/10.1007/s10353-015-0342-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10353-015-0342-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang Y. Department of Surgery, First Affiliated Hospital of Zhengzhou University, No. 54, Building 10, No.2 Huanghe Road, 450008, Zhengzhou City, Henan Province, P. R. China aut NATIONALLICENCE 700 1- Wang J. Department of Surgery, First Affiliated Hospital of Zhengzhou University, No. 54, Building 10, No.2 Huanghe Road, 450008, Zhengzhou City, Henan Province, P. R. China aut NATIONALLICENCE 700 1- Xie J. Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, Zhengzhou, China aut NATIONALLICENCE 700 1- Yang D. Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, USA aut NATIONALLICENCE 700 1- Han G. Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, Zhengzhou, China aut NATIONALLICENCE 700 1- Zhang Y. Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, Zhengzhou, China aut NATIONALLICENCE 700 1- Fu Q. Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, Zhengzhou, China aut NATIONALLICENCE 773 0- European Surgery Springer Vienna 47/5(2015-10-01), 248-253 1682-8631 47:5<248 2015 47 10353