caa a22 4500 606207406 CHVBK 20210128101016.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10353-015-0307-y doi (NATIONALLICENCE)springer-10.1007/s10353-015-0307-y The effects of sulforaphane in the rat model of experimental intestinal ischemia reperfusion [Elektronische Daten] [T. Talih, E. Arslan, E. Sozuer, A. Akcan, H. Akyıldız, M. Akyüz, C. Yazıcı] Summary: Aim: The aim of this study is to investigate the effects of sulforaphane (SFN), which has been shown to protect such organs as the brain, kidneys, liver, and heart against the injury caused by ischemia reperfusion (I-R), on the reperfusion injury in the experimental intestinal I-R model. Material and method: The study employed 30 Wistar albino rats, and there were three groups: the control group (n = 10), I-R group (n = 10), and SFN + I-R group (n = 10). The rats in the control group were sacrificed after a 3-h follow-up subsequent to the laparotomy. The I-R group was subjected to an hour of ischemia and 2h of reperfusion afterward. The SFN + I-R group was administered a dose of 3mg/kg SFN intraperitoneally. The rats were sacrificed after the ileum resection for measurement of tissue malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activity and histopathological analysis. Results: The I-R and SFN + I-R groups were histopathologically shown to have similar cell injuries. In the SFN + I-R group, the increase in GSH-Px activity was higher than SOD activity and both of the increases were statistically significant compared with the control group (p < 0.001). The SFN application did not yield a significant difference in the tissue MDA level compared with the control group. Conclusion: The effect of SFN use on the I-R injury in the intestine did not show an apparent effect histopathologically, although there were statistically significant differences in biochemical parameters. Springer-Verlag Wien, 2015 Ischemia nationallicence Reperfusion nationallicence Sulphoraphane nationallicence Intestine nationallicence Talih T. Kayseri Training and Research Hospital, Kayseri, Turkey aut Arslan E. Faculty of Medicine, Department of Surgery, Bozok University, Yozgat, Turkey aut Sozuer E. Faculty of Medicine, Department of Surgery, Erciyes University, Kayseri, Turkey aut Akcan A. Faculty of Medicine, Department of Surgery, Erciyes University, Kayseri, Turkey aut Akyıldız H. Faculty of Medicine, Department of Surgery, Erciyes University, Kayseri, Turkey aut Akyüz M. Faculty of Medicine, Department of Surgery, Erciyes University, Kayseri, Turkey aut Yazıcı C. Faculty of Medicine, Department of Biochemistry, Erciyes University, Kayseri, Turkey aut European Surgery Springer Vienna 47/2(2015-04-01), 70-74 1682-8631 47:2<70 2015 47 10353 https://doi.org/10.1007/s10353-015-0307-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10353-015-0307-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Talih T. Kayseri Training and Research Hospital, Kayseri, Turkey aut NATIONALLICENCE 700 1- Arslan E. Faculty of Medicine, Department of Surgery, Bozok University, Yozgat, Turkey aut NATIONALLICENCE 700 1- Sozuer E. Faculty of Medicine, Department of Surgery, Erciyes University, Kayseri, Turkey aut NATIONALLICENCE 700 1- Akcan A. Faculty of Medicine, Department of Surgery, Erciyes University, Kayseri, Turkey aut NATIONALLICENCE 700 1- Akyıldız H. Faculty of Medicine, Department of Surgery, Erciyes University, Kayseri, Turkey aut NATIONALLICENCE 700 1- Akyüz M. Faculty of Medicine, Department of Surgery, Erciyes University, Kayseri, Turkey aut NATIONALLICENCE 700 1- Yazıcı C. Faculty of Medicine, Department of Biochemistry, Erciyes University, Kayseri, Turkey aut NATIONALLICENCE 773 0- European Surgery Springer Vienna 47/2(2015-04-01), 70-74 1682-8631 47:2<70 2015 47 10353