caa a22 4500 606209727 CHVBK 20210128101029.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s11220-015-0112-5 doi (NATIONALLICENCE)springer-10.1007/s11220-015-0112-5 Sharma Anuj Department of Applied Sciences, National Institute of Technology Delhi, A-7, Institutional Area, Narela, 110040, Delhi, India aut Model of a Plasmonic Phase Interrogation Probe for Optical Sensing of Hemoglobin in Blood Samples [Elektronische Daten] [Anuj Sharma] Phase interrogation based surface plasmon resonance (SPR) biosensor is proposed for the determination of Hb concentration. Previous experimental results describing variation of refractive index of human blood with Hb concentration at different wavelengths are considered for design simulations. The biosensor design with silica substrate and gold layer is considered. The sensor's performance is closely analyzed in terms of phase sensitivity and resolution. The influence of operating wavelength on biosensor's performance for Hb measurement is critically investigated, which points to carry out the Hb measurement at a shorter wavelength as phase sensitivity and resolution increase significantly with decrease in wavelength. The results are explained in terms of suitable physical concepts such as radiation damping. Use of contamination-preventing biochemical layer ascertains the stability of measurement with the intended SPR biosensor probe. The simulation results also highlight that the resolution of Hb measurement achievable with the proposed biosensor is much higher compared with several existing methods. Springer Science+Business Media New York, 2015 Hemoglobin nationallicence Phase nationallicence Plasmon nationallicence Biosensor nationallicence Sensitivity nationallicence Sensing and Imaging Springer US; http://www.springer-ny.com 16/1(2015-12-01), 1-10 1557-2064 16:1<1 2015 16 11220 https://doi.org/10.1007/s11220-015-0112-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11220-015-0112-5 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Sharma Anuj Department of Applied Sciences, National Institute of Technology Delhi, A-7, Institutional Area, Narela, 110040, Delhi, India aut NATIONALLICENCE 773 0- Sensing and Imaging Springer US; http://www.springer-ny.com 16/1(2015-12-01), 1-10 1557-2064 16:1<1 2015 16 11220